The AnchorSelector parameter of the Popover should support runtime changing. Currently, to change the parameter value, the app must recreate the component by removing it temporarily from the page:
Thank you for the example repl showing the workaround. I also found a workaround that seems to work reliably. Instead of changing the AnchorSelector property, I was able to execute a Javascript code block to perform a click action on a specific element by Id. Then the normal click behavior to show the Popup shows the popup.
-Andy