<TelerikGrid Data="@GridData" RowDraggable="@CanDrag" Class="@DragClass">
    <GridToolBar>
        <GridCommandButton OnClick="@ToggleDrag">Toggle Drag</GridCommandButton>
    </GridToolBar>
    <GridColumns>
        <GridColumn Field="@(nameof(TestModel.Name))" />
    </GridColumns>
</TelerikGrid>

<style>
    .k-grid.hide-drag-column .k-drag-col {
        width: 0;
    }
    .k-grid.hide-drag-column .k-drag-cell {
        visibility: hidden;
    }
</style>

@code {
    bool CanDrag { get; set; } = true;
    string DragClass { get; set; } = "hide-drag-column";

    void ToggleDrag(GridCommandEventArgs args)
    {
        CanDrag = !CanDrag;
    }

    protected override Task OnAfterRenderAsync(bool firstRender)
    {
        if (firstRender)
        {
            CanDrag = false;
            DragClass = "";
        }

        return base.OnAfterRenderAsync(firstRender);
    }

    IEnumerable<TestModel> GridData { get; set; } = Enumerable.Range(1, 5)
        .Select(x => new TestModel {
            ID = x, Name = $"Name {x}"
    });

    public class TestModel
    {
        public string Name { get; set; }
        public int ID { get; set; }
    }
}