Hi, David,

Thank you for bringing this behavior to our attention.

Currently, the possible solution that I can suggest is to set again the desired column's width when the DPI scale factor is changed: 

 this.radVirtualGrid1.RootElement.DpiScaleFactorChanged += RootElement_DpiScaleFactorChanged;
        private void RootElement_DpiScaleFactorChanged(object sender, EventArgs e)
        {
            this.radVirtualGrid1.TableElement.ColumnsViewState.SetItemSize(0, 50);
        }

I believe that it would fit your scenario.

Regards,
Dess | Tech Support Engineer, Principal
Progress Telerik