Bind the grid to the following DataTable:
DataTable dt = new DataTable();
dt.Columns.Add("X.Y");
dt.Columns.Add("X");
dt.Rows.Add("Data X.Y", "Data X");
this.radGridView1.DataSource = dt;
You will notice that the second column "X" is missing.
Note: if you change the order of adding the columns, both columns will be added.