How to reproduce public partial class Form1 : RadForm { public Form1() { InitializeComponent(); GridViewTextBoxColumn textBoxColumn = new GridViewTextBoxColumn(); textBoxColumn.Name = "Column"; textBoxColumn.HeaderText = "Column"; this.radGridView1.MasterTemplate.Columns.Add(textBoxColumn); GridViewTextBoxColumn textBoxColumn2 = new GridViewTextBoxColumn(); textBoxColumn2.Name = "TextBoxColumn2"; textBoxColumn2.HeaderText = "ReadOnlyColumn"; this.radGridView1.MasterTemplate.Columns.Add(textBoxColumn2); for (int i = 0; i < 10; i++) { object v = i * 2; if (i % 3 == 0) { v = null; } this.radGridView1.Rows.Add(new object[] { i, v }); } this.radGridView1.MultiSelect = true; foreach (var row in this.radGridView1.Rows) { foreach (var cell in row.Cells) { GridViewCellInfo cellInfo = cell as GridViewCellInfo; if (cellInfo != null && cellInfo.RowInfo.Index % 3 == 0 && cellInfo.ColumnInfo.Index == 1) { cellInfo.ReadOnly = true; } } } } } Workaround: public class MyRadGridView : RadGridView { public override string ThemeClassName { get { return typeof(RadGridView).FullName; } } protected override RadGridViewElement CreateGridViewElement() { return new MyRadGridViewElement(); } } internal class MyRadGridViewElement : RadGridViewElement { protected override Type ThemeEffectiveType { get { return typeof(RadGridViewElement); } } protected override MasterGridViewTemplate CreateTemplate() { return new MyMasterGridViewTemplate(); } } internal class MyMasterGridViewTemplate : MasterGridViewTemplate { protected override void PasteDataToRow(List<string> rowData, GridViewRowInfo row) { { int colIndex = this.Owner.CurrentColumn.Index; int j = 0; while (j < rowData.Count && colIndex < this.CurrentView.ViewTemplate.ColumnCount) { GridViewColumn col = this.CurrentView.ViewTemplate.Columns[colIndex]; if (col.IsVisible && !col.ReadOnly && !row.Cells[colIndex].ReadOnly) { object value = rowData[j]; if (string.IsNullOrEmpty(rowData[j])) { value = null; } else if (this.CurrentView.ViewTemplate.Columns[colIndex].DataType == typeof(string)) { GridViewTextBoxColumn textColumn = col as GridViewTextBoxColumn; if (textColumn != null && textColumn.MaxLength > 0) { if (rowData[j].Length > textColumn.MaxLength) { value = rowData[j].Substring(0, textColumn.MaxLength); } } } else if (this.CurrentView.ViewTemplate.Columns[colIndex].DataType == typeof(DateTime)) { try { value = DateTime.Parse(rowData[j], this.CurrentView.ViewTemplate.Columns[colIndex].FormatInfo); } catch { } } else if (this.CurrentView.ViewTemplate.Columns[colIndex].DataType == typeof(Color)) { try { value = ColorTranslator.FromHtml(rowData[j]); } catch { } } if (this.ClipboardPasteMode == GridViewClipboardPasteMode.EnableWithNotifications) { CellValidatingEventArgs cellValidating = new CellValidatingEventArgs(row, col, value, row.Cells[colIndex].Value, null); this.EventDispatcher.RaiseEvent<CellValidatingEventArgs>(EventDispatcher.CellValidating, this, cellValidating); if (!cellValidating.Cancel) { row.Cells[colIndex].Value = value; CellValidatedEventArgs cellValidated = new CellValidatedEventArgs(row, col, value); this.EventDispatcher.RaiseEvent<CellValidatedEventArgs>(EventDispatcher.CellValidated, this, cellValidated); } } else { row.Cells[colIndex].Value = value; } j++; } colIndex++; } } } }