To reproduce:

public partial class RadRibbonForm1 : Telerik.WinControls.UI.RadRibbonForm
    {
        public RadRibbonForm1()
        {
            InitializeComponent();
            this.AllowAero = true;
            this.RibbonBar.QuickAccessToolbarBelowRibbon = false;
        }
    }

Note: the system buttons not always handle the mouse click.

Workaround: set AllowAero to false OR RibbonBar.QuickAccessToolbarBelowRibbon to true.