To reproduce: if you set in the app.manifest file  <dpiAware>false</dpiAware>, the controls still scale when changing DPI.

Workaround:
Public Class RadForm1
    Protected Overrides Sub OnLoad(e As EventArgs)

        Dim allowTheming = DirectCast(GetType(RadForm).GetField("allowTheming", BindingFlags.Instance Or BindingFlags.NonPublic).GetValue(Me), Boolean?)

        Dim behavior As ThemedFormBehavior = TryCast(Me.FormBehavior, ThemedFormBehavior)
        If behavior IsNot Nothing AndAlso allowTheming.HasValue AndAlso behavior.AllowTheming <> Me.AllowTheming Then
            behavior.AllowTheming = allowTheming.Value
        End If

        If Me.IsDesignMode Then
            GetType(RadFormControlBase).GetField("initialFormLocation", BindingFlags.Instance Or BindingFlags.NonPublic).SetValue(Me, Me.Location)

            Return
        End If

        Dim mi As MethodInfo = GetType(Form).GetMethod("OnLoad", BindingFlags.Instance Or BindingFlags.NonPublic)
        Dim ptr As IntPtr = mi.MethodHandle.GetFunctionPointer()
        Dim formOnOnLoad As Action(Of EventArgs) = DirectCast(Activator.CreateInstance(GetType(Action(Of EventArgs)), Me, ptr), Action(Of EventArgs))

        formOnOnLoad(e)
    End Sub

End Class