Workaround:
 Sub New()

     InitializeComponent()

     AddHandler RadMessageBox.Instance.LocationChanged, AddressOf MsgLocationChanged
 End Sub
 Private Sub RadTreeView1_NodeMouseClick(sender As Object, e As Telerik.WinControls.UI.RadTreeViewEventArgs) Handles RadTreeView1.NodeMouseClick
     If RadMessageBox.Show(Me, String.Format("Change Project to {0}{1}{0}?", Chr(34), e.Node.Text), "Change Project", MessageBoxButtons.YesNo, _
                           RadMessageIcon.Question, MessageBoxDefaultButton.Button1) = Windows.Forms.DialogResult.Yes Then
     End If

 End Sub

 Private Sub MsgLocationChanged(sender As Object, e As EventArgs)
     RadMessageBox.Instance.Location = New Point(Me.Location.X + Me.Width / 2, Me.Location.Y + Me.Height / 2)
 End Sub