To reproduce: public Form1() { InitializeComponent(); GridViewComboBoxColumn comboCol = new GridViewComboBoxColumn(); comboCol.DataSource = InitComboActive(); comboCol.ValueMember = "ActiveCode"; comboCol.DisplayMember = "ActiveDsc"; comboCol.FieldName = "ActiveCode"; this.radGridView1.Columns.Add(comboCol); this.radGridView1.AutoGenerateColumns = false; BindRadGrid(); this.radGridView1.CellValueChanged += radGridView1_CellValueChanged; } private void radGridView1_CellValueChanged(object sender, GridViewCellEventArgs e) { BindRadGrid(); } private void BindRadGrid() { this.radGridView1.DataSource = null; this.radGridView1.DataSource = InitComboData(); } private DataTable InitComboActive() { DataTable dt = new DataTable("DtActive"); dt.Columns.Add("ActiveCode"); dt.Columns.Add("ActiveDsc"); dt.Rows.Add("0", "InActive"); dt.Rows.Add("1", "Active"); return dt; } private DataTable InitComboData() { DataTable dt = new DataTable("DtData"); dt.Columns.Add("Host"); dt.Columns.Add("ActiveCode"); dt.Columns.Add("ActiveDsc"); dt.Rows.Add("Host A", "0", "InActive"); dt.Rows.Add("Host B", "1", "Active"); return dt; } Workaround: use the RadGridView.CellEndEdit instead for rebinding. Workaround 2: use the CellValidated event: private void radGridView1_CellValidated(object sender, CellValidatedEventArgs e) { if (e.Row is GridViewDataRowInfo) { BindRadGrid(); } }