How to reproduce: check the attached project Workaround: use a custom RadPanel control: public class MyRadPanel : RadPanel { protected override bool ProcessMnemonic(char charCode) { if (!Control.IsMnemonic(charCode, this.Text)) { return false; } if (!this.Enabled || !this.Visible) { return false; } Control parentInternal = this.Parent; if (parentInternal != null) { if (parentInternal.SelectNextControl(this, true, false, true, false) && !parentInternal.ContainsFocus) { parentInternal.Focus(); } } return true; } }