To reproduce: make sure only the first row is selected then Shift select row 3. DataTable dt = new DataTable(); dt.Columns.Add("Value", typeof(int)); dt.Columns.Add("Date", typeof(DateTime)); dt.Columns.Add("Description", typeof(string)); for (int index = 0; index < 15; index++) { dt.Rows.Add(new object[] { index % 5, DateTime.Now.AddSeconds(10), "Index = " + index }); } radGridView1.DataSource = dt; radGridView1.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill; radGridView1.MultiSelect = true; foreach (GridViewColumn col in this.radGridView1.Columns) { ConditionalFormattingObject obj = new ConditionalFormattingObject("Value", ConditionTypes.Equal, col.Index.ToString(), "", true); obj.RowBackColor = Color.SkyBlue; obj.RowForeColor = Color.Red; obj.TextAlignment = ContentAlignment.MiddleRight; obj.ApplyOnSelectedRows = false; this.radGridView1.Columns[0].ConditionalFormattingObjectList.Add(obj); } Workaround: use the CellFormatting event to apply the desired formatting by using the API for overriding theme settings: http://docs.telerik.com/devtools/winforms/gridview/cells/formatting-cells http://docs.telerik.com/devtools/winforms/telerik-presentation-framework/override-theme-settings-at-run-time