You can set the UseCompatibleTextRenderingDefaultValue property to false in order to change the default value of compatible text rendering for all RadControls. It is recommended to set it before InitializeComponent(). The provided example below demonstrates how to achieve it: 

public partial class Form1 : Form
{
    public Form1()
    {
        RadControl.UseCompatibleTextRenderingDefaultValue = false;  
        InitializeComponent();                    
    }
}