Changing the DataSource or scrolling are slow. Create a grid with more than 20 columns and add 5K rows for example. Maximize the form and try to scroll with mouse wheel. You will notice that the scrolling performance is worse compared to the normal state of the form with less visible visual elements. Workaround: this.radGridView1.EnableFastScrolling = true; and use the scrollbar's thumb Second workaround: use paging: https://docs.telerik.com/devtools/winforms/gridview/paging/overview Thus, you will display as many rows as possible to display on the screen per page. Instead of scrolling, you will navigate through pages.