To reproduce: Set these properties: radGridView1.SelectionMode = GridViewSelectionMode.FullRowSelect; radGridView1.MultiSelect = true; Select a row, hold Ctrl and click the same cell which is selected, you will see that the SelectionChanging event, along with the SelectionChanged one will not be fired. Workaround: Use the PropertyChanging event of the rows: this.Grid.Rows.ToList().ForEach(x => x.PropertyChanging += x_PropertyChanging); .... void x_PropertyChanging(object sender, Telerik.WinControls.Interfaces.PropertyChangingEventArgsEx e) { if (e.PropertyName == "IsSelected") { } }