FIX. RadDropDownList - Autocomplete dropdown is not refreshed after changing the data source To reproduce: 1 - Add a RadDropDownList and a RadButton to the form. Use the following code snippet: public Form1() { InitializeComponent(); this.radButton1.Click+=radButton1_Click; SetDomain("AA"); this.radButton1.Text = "Set to BB"; } private void radButton1_Click(object sender, EventArgs e) { if (this.radButton1.Text == "Set to AA") { SetDomain("AA"); this.radButton1.Text = "Set to BB"; } else { SetDomain("BB"); this.radButton1.Text = "Set to AA"; } } DataTable parentDataTable; public void SetDomain(string name) { parentDataTable = new DataTable("Data"); parentDataTable.Columns.Add("P1", typeof(decimal)); parentDataTable.Columns.Add("P2", typeof(string)); for (int x = 1; x <= 5; x++) { parentDataTable.Rows.Add(x, name + x.ToString()); } this.radDropDownList1.DataSource = parentDataTable; this.radDropDownList1.DisplayMember = "P2"; this.radDropDownList1.ValueMember = "P1"; this.radDropDownList1.DropDownStyle = RadDropDownStyle.DropDown; this.radDropDownList1.AutoCompleteMode = AutoCompleteMode.SuggestAppend; this.radDropDownList1.DropDownListElement.AutoCompleteSuggest.SuggestMode = SuggestMode.Contains; this.radDropDownList1.SelectedValue = null; this.radDropDownList1.Text = ""; } 2 - Type A to get dropdown list with AA1 to AA5 3 - Escape to collapse the list 4 - Click the "Set to BB" button 5 - Type A again in the list and again AA1 to AA5 is presented even though the datatable now contains BB1 to BB5 6 - Click on the dropdown arrow repeatedly and the dropdown list toggles between AA and BB lists. Workaround: before setting the DataSource property, set it to null and clear the Items list: this.radDropDownList1.DataSource = null; this.radDropDownList1.Items.Clear();