To reproduce, add RadMultiColumnCombobox on a form and use the following code:

  public Form1()
        {
            InitializeComponent();

            Random r = new Random();
            DataTable table = new DataTable();

            table.Columns.Add("ID", typeof(int));
            table.Columns.Add("Name", typeof(string));
            table.Columns.Add("Bool", typeof(bool));
            table.Columns.Add("DateColumn", typeof(DateTime));

            for (int i = 0; i < 10; i++)
            {
                table.Rows.Add(i, "Row " + i, r.Next(10) > 5 ? true : false, DateTime.Now.AddHours(i));
            }

            radMultiColumnComboBox1.DataSource = table;
            radMultiColumnComboBox1.DisplayMember = "Name";
            radMultiColumnComboBox1.AutoFilter = true;
            radMultiColumnComboBox1.DisplayMember = "Name";
            FilterDescriptor filter = new FilterDescriptor();
            filter.PropertyName = radMultiColumnComboBox1.DisplayMember;
            filter.Operator = FilterOperator.Contains;
            radMultiColumnComboBox1.EditorControl.MasterTemplate.FilterDescriptors.Add(filter);
        }

Once the form loads up, select the text in the editable area and enter any number from 0 to 9. It is important the width of the MCCB is smaller than the width the columns take.