If one is using the AutoFilter functionality and want's to select the very first row of the filtered grid, s\he is not able to do so by the keyboard. Resolution: Selection of first row with keyboard is introduced in our KB article Use custom filtering to search in all columns of RadMultiColumnComboBox. Please take a look at the following link http://www.telerik.com/support/kb/winforms/details/use-custom-filtering-to-search-in-radmulticolumncombobox