To reproduce: Add a RadForm as MDI child to another form. Add RadMenu to the child and the main forms. Associate hotkeys as follows: RadMenuItem item = new RadMenuItem; item.Text = "&File"; You will notice that only the main menu can be accessed with the Alt key and the shortcut. Workaround: Subscribe for each childform's KeyUp event and use the following event handler: private void childForm_KeyUp(object sender, KeyEventArgs e) { Form form = sender as Form; if (!form.Focused) { return; } RadMenu menu = null; foreach (Control control in form.Controls) { if (control is RadMenu) { menu = control as RadMenu; break; } } if ((Control.ModifierKeys & Keys.Alt) == Keys.Alt && menu != null) { foreach (RadItem item in menu.Items) { int ampersantIndex = item.Text.IndexOf("&"); if (ampersantIndex != -1) { char hotkeyChar = item.Text[ampersantIndex + 1]; if (char.ToLower(hotkeyChar) == char.ToLower((char)e.KeyValue)) { item.PerformClick(); break; } } } } }