PouchDB is a great way to both persist and sync data. It would be beneficial for DataSource to support PouchDB database, the way it currently supports SignalR and OData. Here's PouchDB site: http://pouchdb.com
Thanks for the proposal, terikon. Presently a possible option for you might be to define custom transport definitions (http://docs.telerik.com/kendo-ui/api/javascript/data/datasource#configuration-transport) in order to load and process data from PouchDB.
For now I started to implement this functionality myself. Here's kendo-pouchdb adapter: https://github.com/terikon/kendo-pouchdb