Setting the theme via the StyleManager.SetTheme(control, theme) method does not style the cell as expected when a CellStyle is defined for its parent column. The current workaround is to explicitly set the theme via the style: <Style x:Key="BlueCellStyle" TargetType="telerik:GridViewCell"> <Setter Property="Background" Value="PowderBlue"/> <Setter Property="telerik:StyleManager.Theme" Value="VisualStudio2013" /> </Style>