The exception throws when you use RadDiagram in a data binding scenario by populating its GraphSource and you want to draw a shape using the RadDiagramRibbon's ShapeTool. 

InvalidOperationException: 'Cannot modify the Items collection when the GraphSource is set.'

To work this around, use the PreviewMouseDown, PreviewMouseMove and PreviewMouseUp events of RadDiagram in order to prevent the default logic executed by the ShapeTool. Then, in the event handlers, implement a custom logic that works with the diagram GraphSource.

private void RadDiagramRibbon_Loaded(object sender, RoutedEventArgs e)
{
	var toolService = diagram.ServiceLocator.GetService<IToolService>() as ToolService;
	this.shapeTool = (ShapeTool)toolService.ToolList.FirstOrDefault(x => x is ShapeTool);
}

private Point startPoint;
private bool isShapeCreationInProgress;
private MyNode currentShapeModel; // where MyNode derives from NodeViewModelBase and expose an additional Geometry property 
private ShapeTool shapeTool;

private void RadDiagram_PreviewMouseDown(object sender, MouseButtonEventArgs e)
{			
	if (this.shapeTool.IsActive && !this.isShapeCreationInProgress)
	{
		this.isShapeCreationInProgress = true;
		this.startPoint = this.diagram.GetTransformedPoint(e.GetPosition(this.diagram));

		this.currentShapeModel = new MyNode()
		{
			Geometry = this.shapeTool.Geometry,
			Position = this.startPoint,
			Width = 0,
			Height = 0
		};
		var source = (MyGraphSource)this.diagram.GraphSource;
		source.AddNode(this.currentShapeModel);
		e.Handled = true;
	}
}

private void RadDiagram_PreviewMouseMove(object sender, MouseEventArgs e)
{
	if (this.shapeTool.IsActive && this.currentShapeModel != null && this.isShapeCreationInProgress)
	{
		var transformedPoint = this.diagram.GetTransformedPoint(e.GetPosition(this.diagram));
		var width = Math.Abs(this.startPoint.X - transformedPoint.X);
		var height = Math.Abs(this.startPoint.Y - transformedPoint.Y);
		var x = Math.Min(this.startPoint.X, transformedPoint.X);
		var y = Math.Min(this.startPoint.Y, transformedPoint.Y);

		this.currentShapeModel.Width = width;
		this.currentShapeModel.Height = height;
		this.currentShapeModel.Position = new Point(x, y);
		e.Handled = true;
	}
}

private void RadDiagram_PreviewMouseUp(object sender, MouseButtonEventArgs e)
{
	this.isShapeCreationInProgress = false;
	e.Handled = true;
}

RadDiagram with virtualization turned off.

Randomly positioned 5000 shapes are added in Diagram.

For the test, Shapes are with simplified template consisting pretty much of a single Border and nothing else.

On maximized WPF window, Diagram Load for about 3-3.5 seconds.

On normal WPF window, DIagram loads for about 15 seconds.

I looked at the RadDiagram options, but it doesn't have anything that compares to a circular relationship chart.  Here's an example:

https://www.codeproject.com/KB/silverlight/342715/screenshot2.png

Part of this article:

https://www.codeproject.com/Articles/342715/Plotting-Circular-Relationship-Graphs-with-Silverl

I gave some thought at trying to rewrite the code into WPF, but I've got too many other irons in the fire.  Figured I'd ask as this sort of visualization control doesn't appear in your current collection.  I have a project that could benefit from displaying weighted relationships in such a manner, but my choices are either do something sub-par with the RadDiagram option, write one myself, find another controls collection and port everything, or leave the feature out for now.  I'm going for the leave it out option for the moment, and see if your UI wizards can come up with something...

Just as a use case, one of the reasons for wanting this is to diagram conversations between individuals in email messages.  Being able to show who's talking to whom and how frequently using one of these charts for visualization allows you to quickly find patterns...

While performing Cut operation inside RadDiagram, an exception in the MS Clipboard occurs with the following message:

System.Runtime.InteropServices.COMException: 'OpenClipboard Failed (Exception from HRESULT: 0x800401D0 (CLIPBRD_E_CANT_OPEN))'

Currently large diagrams are hard to export with good quality because of the memory limitation in WritableBitmap when the DPI is increased.

 -- One option is to use BitMapCacheBrush (discussed here http://www.telerik.com/forums/low-resolution-using-exporttoimage-on-big-diagram)

 -- Another option is to export multiple images of the diagram which cover it all. Then possibly combine these pictures into one.

 -- Also , you can try increasing the operating memory of your Visual Studio

If we have a custom shape that derives from RadDiagramShapeBase and we rotate it at some degree (90) for example, and then resize it the diagram's selection adorner is misplaced with the shape.

Workaround:
Set RenderTransofrmOrigin = new Point(0.5, 0.5) to the shape.
Other workaround:
Derive the custom shape from RadDiagramShape, instead of RadDiagramShapeBase. 

To reproduce this use the following code snippet:

Steps to reproduce:

1. Start a new connection from Shape 1, by dragging one of its connectors.
2. Drag the connection over Shape 2. 

Expected: The connector closest to the mouse should get highlighted and when you drop the connection it should get attached to the shape.
Actual: The closest connector is not highlighted. Also, when you drop the connection over the target shape it doesn't get attached.

The exception is thrown for the RotationAngle property.

The issue can be observed also in the opposite direction - the diagram is serialized on a machine with some culture (for example Portugal Porguese - pt-PT) and then restored on a machine with an English culture.

The issue reproduces only when saving and loading between cultures which numeric separators are different. For example, with Bulgarian culture, the number 4.5 is represented as 4,5 (with a comma). With English culture the number will be represented as 4.5 (with a period).

To work this around, create a custom RadDiagramShape and override its Deserialize() method. Then parse the RotationAngle manually, and set it to the RotationAngle property of the shape. After this, set the RotationAngle of the SerializationInfo to null, in order to prevent the default restoring of the property.

Currently, the print preview control provides only options for the current printer, the page orientation and the page size . Include the following options too:

 - Paper Format (Lettre, A4, etc.)
 - Paper Orientation (Portrait or Landscape)
 - Number of copies (1, 2, 3, ...)
 - Print Color Settings (Colors or Monochrome)
 - Margins
 - Resolution (DPI based on the capabilities of the printer)

When zooming out on more than 500-600 shapes and then panning, if telerik:DiagramSurface.IsVirtualizing="True", the performance is slower. 

When virtualization is off, the performance is a little better.

Connect the Diagrams BackgroundGrid to the Ruler's Measurement Unit and ScaleDefinitions.

Currently only in DPI measurement unit the scaledefinitions and diagram background grid look good and consistent.

A possible workaround is to use an attached property. Basically, we've added ConnectionPointsProperty in AttachedProperties class and added binding to this new property in the style of the connection.

public class AttachedProperties
    {
        public static RadDiagram Diagram { get; set; }

        public static readonly DependencyProperty ConnectionPointsProperty =
           DependencyProperty.RegisterAttached("ConnectionPoints", typeof(List<Point>), typeof(AttachedProperties), new PropertyMetadata(null, OnConnectionPointsChanged));

        public static IEnumerable<Point> GetConnectionPoints(DependencyObject obj)
        {
            return (IEnumerable<Point>)obj.GetValue(ConnectionPointsProperty);
        }

        public static void SetConnectionPoints(DependencyObject obj, IEnumerable<Point> value)
        {
            obj.SetValue(ConnectionPointsProperty, value);
        }

        private static void OnConnectionPointsChanged(DependencyObject d, DependencyPropertyChangedEventArgs e)
        {
            var connection = d as RadDiagramConnection;
            var connectionPoints = e.NewValue as List<Point>;
            if (connection != null && connectionPoints != null)
            {
                for (int i = 0; i <  connectionPoints.ToList().Count; i++)
                {
                    connection.ConnectionPoints.Add(connectionPoints.ToList()[i]);                 
                }
                connection.IsModified = true;
                (connection as IConnection).Update();
            }
        }
    }



  <telerik:RadDiagram.ConnectionStyle>
                <Style TargetType="telerik:RadDiagramConnection">
                    <Setter Property="ConnectionType" Value="Polyline"/>
                    <Setter Property="local:AttachedProperties.ConnectionPoints" Value="{Binding MyConnectionPoints}"/>
                </Style>
            </telerik:RadDiagram.ConnectionStyle>