Generated item cache is not cleared properly. This leads to memory leaking when items are virtualized and realized. 

As a workaround you can set the IsVisualCacheEnabled property of the TreeViewPanel to False. Note that this will work only in Recycling VirtualizationMode.

<telerik:RadTreeView.ItemsPanel>
    <ItemsPanelTemplate>
        <telerik:TreeViewPanel IsVisualCacheEnabled="False" />
    </ItemsPanelTemplate>
</telerik:RadTreeView.ItemsPanel>