Customers are reporting an issue when trying to copy content in an application hosted on a remote machine (there are reports using TigerVNC and Citrix). The exception is thrown from the Clipboard class with a message: OpenClipboard failed (Exception from HRESULT: 0x800401D0 (CLIPBRD_E_CANT_OPEN)) It seems like such a behavior could be reproduced when the clipboard is already opened by another application. Here is a discussion on the matter: https://stackoverflow.com/questions/68666/clipbrd-e-cant-open-error-when-setting-the-clipboard-from-net