When the UI culture changes, the DataMemberBinding is updated for all columns (I'm wondering why?). See \Controls\GridView\GridView\GridView\GridViewDataControl.cs:

private void UpdateCultureInfoIfNeeded()
{
	if (this.cultureInfo != null && (this.cultureInfo.Name.ToUpper(this.cultureInfo) != this.Language.IetfLanguageTag.ToUpper(this.cultureInfo)))
	{
		this.InitializeCultureInfo();
		foreach (var column in this.Columns.OfType<GridViewBoundColumnBase>())
		{
			Binding oldBinding = column.DataMemberBinding.CloneBinding(column.ValidatesOnDataErrors);
			column.DataMemberBinding = oldBinding;
		}
	}
}

However, if the DataMemberBinding was null, the CloneBinding creates a new binding with empty path instead of returning null again - but this never makes sense for the DataMemberBinding on a column (crashes the application as soon as the Binding is applied to the cells).

Background: I have created a column where the cell value is not bound but dynamically calculated - so the DataMemberBinding is null.