Should be clicked somewhere else afterwards in order to refresh the cursor. The fix is available in R2 2016 SP1.
As a workaround of the issue you could manually release the mouse capture in the SelectionChanged event handler of the control as shown below: private void radAutoCompleteBox_SelectionChanged(object sender, SelectionChangedEventArgs e) { if (e.RemovedItems.Count > 0) { if (Mouse.Captured is RadAutoCompleteBox) { (sender as RadAutoCompleteBox).ReleaseMouseCapture(); } } } Regards, Atanas Telerik