When using similar code as below, RadComboBox does not select the specified item. If the DomainDataSource data was already loaded, the selection is successful. <telerikInput:RadComboBox ItemsSource="{Binding ElementName=MineTypeDomainDataSource, Path=Data}" SelectedItem="{Binding Path=MineType, Mode=TwoWay, NotifyOnValidationError=true, ValidatesOnExceptions=true}"> <telerikInput:RadComboBox.ItemTemplate> <DataTemplate> <TextBlock Text="{Binding MineTypeName}" HorizontalAlignment="Left" /> </DataTemplate> </telerikInput:RadComboBox.ItemTemplate> </telerikInput:RadComboBox> <riaControls:DomainDataSource AutoLoad="True" x:Name="MineTypeDomainDataSource" QueryName="GetMineTypesQuery" LoadedData="MineTypeDomainDataSource_LoadedData" DomainContext="{StaticResource CitationDBSvc}" />