Calling EnumeratePanes() after reordering RadPanes into a RadPaneGroup using drag and drop returns the panes in wrong other.This causes another issue. When saving the layout by using the SaveLayout method, the RadPanes are saved in wrong order. For a workaround you can check the following thread: http://www.telerik.com/forums/panes-in-documenthost-not-saved-in-display-order "You can then fix the problem as follows: 1. Read the RadPaneGroup.Items collection and extract the SerializationTag for each pane to a list. This list contains the correct order which you want to save. 2. Save the docking layout using the SaveLayout() method on the main docking control and extract the XML as a string as you normally would. But do not save it to a file just yet. 3. Create an XML document using XDocument and parse the XML string. 4. Extract a list of all elements of type "RadDocumentPane" using the Descendants() method and sort these in the right order using the ordered list you created in step 1. 5. Locate the RadPaneGroup for the DocumentHost and delete all elements of the child element "Items". 6. Add the sorted elements from step 4 back into the RadPaneGroup.Items container. 7. Save the result to a textfile."