As we can find in telerik documentations, there are various controls properties that can be set from web.config. Like skin, render mode, etc.
It is done with a list of keys under <appSettings> section in the web.config. See link below.
https://docs.telerik.com/devtools/aspnet-ajax/general-information/web-config-settings-overview#control-properties-you-can-set-from-the-webconfig

My sugestion is to add in this list the localization path property. So we can centralize the resources files location for big projects, like a web site under IIS with many webapplication under one site.