The Ajax in the sample page is made using: $find("<%= RadAjaxManager.GetCurrent(Page).ClientID %>").ajaxRequest(); In on the page the AjaxManger updates the panel, in the other the setting is that the proxy should update the panel. This is invalid setting. <telerik:AjaxSetting AjaxControlID="RadAjaxManagerProxy1" > <UpdatedControls> <telerik:AjaxUpdatedControl ControlID="rsLeftPanel" LoadingPanelID="ralp1" /> </UpdatedControls> </telerik:AjaxSetting> The correct way of doing this is to use add the settings programatically, or to use the ajaxRequestWithTarget instead of ajaxRequest method http://docs.telerik.com/devtools/aspnet-ajax/controls/ajax/radajaxmanager/how-to/add-ajaxsettings-programmatically