Programmatic configuration of the data binding of markers is unavailable from the code behind.  

For example:
 RadMap1.DataBindings.MarkerBinding.DataShapeField = "Shape";
 RadMap1.DataBindings.MarkerBinding.DataTitleField = "City";
 RadMap1.DataBindings.MarkerBinding.DataLocationLatitudeField = "Latitude";
 RadMap1.DataBindings.MarkerBinding.DataLocationLongitudeField = "Longitude";