Reference: http://www.telerik.com/forums/radgrid-column-header-and-data-item-alignment-problem This has apparently been an issue with RadGrid for a long time, according to the above thread. I have done a significant amount of testing to isolate this bug and have attached a self-contained solution in VB.NET 4.0 (VS 2010). I removed all the surplus RadGrid properties I could in order to simplify the debugging process on your end and included my notes in the code and on the test page. There is indeed some peculiar behavior with the control. Regards, Matthew