For the time being the following CSS workaround can be used:
CSS:
    <style type="text/css">
        .RadButton.rbSkinnedButton input {
            padding-left: 6px;
            padding-right: 10px;
            margin: 0;
        }
    </style>
ASPX:
        <telerik:RadComboBox ID="RadComboBoxDateTimeFilter" runat="server">
            <ItemTemplate>
                <telerik:RadButton ID="RadButtonApply" Text="Apply" AutoPostBack="false" runat="server" />
                <telerik:RadButton ID="RadButtonClear" Text="Clear" AutoPostBack="false" runat="server" />
            </ItemTemplate>
            <Items>
                <telerik:RadComboBoxItem Text="" Value="" Selected="true" />
                <telerik:RadComboBoxItem Text="" Value="" />
            </Items>
        </telerik:RadComboBox>