For the time being the property can be set on the client through the chartObject. For example:
JavaScript:
	<script>
		function pageLoad() {
			var chart = $find("<%=RadHtmlChart1.ClientID%>");
			chart._chartObject.options.series[0].highlight = {
				markers: {
					visible: true
				}
			}
			chart.repaint();
		}
	</script>
ASPX:
		<telerik:RadHtmlChart ID="RadHtmlChart1" runat="server" Width="600" Height="400">
			<PlotArea>
				<Series>
					<telerik:LineSeries>
						<MarkersAppearance Visible="false" />
						<SeriesItems>
							<telerik:CategorySeriesItem Y="30" />
							<telerik:CategorySeriesItem Y="10" />
							<telerik:CategorySeriesItem Y="20" />
							<telerik:CategorySeriesItem Y="15" />
						</SeriesItems>
					</telerik:LineSeries>
				</Series>
			</PlotArea>
		</telerik:RadHtmlChart>