I hate the stupid asp script managers...they're so ghetto with the .axd files always hosing our yslow\pagespeed scores, etc.
Since your focus is no on css3\html5\lightweight rendering can you guys not come up a better way to bundle your scripts such that they render properly cached to the footer...maybe take a dependancy for that on system.web.optimization or something?
...maybe some sort of requireJS integration or...?
Please feel free to think out of the box instead of being stuck into the asp.net crapballs bloat framework.