Changing the DPI settings to 125%, for example, on Windows 7 causes troubles with the Desktop clicks when running tests against Chrome. The click is below or above the target element. Highlighting in record mode may also be affected.
Workaround: As a workaround the Desktop clicks (MouseClick() method) can be replaced with the Click() method, which works as expected. The alternative in a non-coded solution is to disable the 'SimulateRealClick' option for the click steps.