Playback of a test recorded in Chrome against a specific customer website fails with:
'11/21/2014 6:46:17 PM' - 'Fail' : 6. Click 'YUTag'
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Failure Information: 
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Unable to find the target host (Browser/SilverlightApp) to locate an element. Failure: Waiting for frame '[Frame:id=RAD_SPLITTER_PANE_EXT_CONTENT_ctl00_rightPane,name=ctl00_rightPane,src=http://67.216.69.16:9090/applets/payroll/edit.aspx,UseQuery:False]' timed out. Error: Wait for condition has timed out
InnerException:
System.Exception: Unable to find the target host (Browser/SilverlightApp) to locate an element. Failure: Waiting for frame '[Frame:id=RAD_SPLITTER_PANE_EXT_CONTENT_ctl00_rightPane,name=ctl00_rightPane,src=http://67.216.69.16:9090/applets/payroll/edit.aspx,UseQuery:False]' timed out. Error: Wait for condition has timed out
   at ArtOfTest.WebAii.Design.Execution.ExecutionUtils.WaitForAllElements(IAutomationHost host, AutomationDescriptor descriptor, Int32 timeout)
   at ArtOfTest.WebAii.Design.Execution.ExecutionEngine.ExecuteStep(Int32 order)

Recording the exact same sequence works perfectly when using IE.