Use attached to reproduce.

With versions prior 2015.3.930 the results are different.

To reproduce:
Public Class RadForm1
    Public RadGridView1 As RadGridView

    Private Sub RadForm1_Load(sender As Object, e As EventArgs) Handles Me.Load
        CreateGrid()
        FormatGrid()
        SetDataSource()
    End Sub

    Private Sub CreateGrid()
        Try
            RadGridView1 = New RadGridView
            Me.Controls.Add(RadGridView1)
        Catch ex As Exception
            MessageBox.Show(Me, ex.Message)
        End Try
    End Sub
    Private Sub FormatGrid()

        Dim col As GridViewTextBoxColumn
        With RadGridView1
            col = New GridViewTextBoxColumn
            With col
                .FieldName = "FieldID"
                'NOTE: Comment out NullValue = "" to prevent the unhandled exception
                .NullValue = ""
            End With
            .Columns.Add(col)
        End With
    End Sub
    Private Sub SetDataSource()
        Dim table As DataTable = Nothing
        Dim row As DataRow = Nothing
        table = New DataTable("GridList")
        table.Columns.Add("FieldID", GetType(System.Guid))
        row = table.NewRow
        row("FieldID") = Guid.Empty
        table.Rows.Add(row)
        RadGridView1.DataSource = table
    End Sub
End Class

Workaround:
Comment this line 
NullValue = ""

I have a GridView (Winforms v. 2017.3.1017.40, same problem with 2017.2.502.40) configured as on the attached screenshot (made some groups, made a search, and used the "excel-like" filter on a column to uncheck some values).

Then I try to click on some column headers to sort the grid.
After a few clicks, I get this error :
InvalidOperationException: La collection a été modifiée ; l'opération d'énumération peut ne pas s'exécuter.

I got different stacktrace with the same error :
InvalidOperationException: La collection a été modifiée ; l'opération d'énumération peut ne pas s'exécuter.
   at System.ThrowHelper.ThrowInvalidOperationException(ExceptionResource resource)
   at System.Collections.Generic.List`1.Enumerator.MoveNextRare()
   at System.Collections.Generic.List`1.Enumerator.MoveNext()
   at Telerik.WinControls.UI.DataGroup.<GetEnumerator>d__0.MoveNext()
   at Telerik.WinControls.UI.GridViewGroupRowInfo.get_ChildRows()
   at Telerik.WinControls.UI.GridViewRowInfo.HasChildRows()
   at Telerik.WinControls.UI.PrintGridTraverser.CanStepInHierarchy()
   at Telerik.WinControls.UI.GridTraverser.StepInHierarchy()
   at Telerik.WinControls.UI.GridTraverser.MoveNextCore()
   at Telerik.WinControls.UI.GridTraverser.MoveNext()
   at Telerik.WinControls.UI.GridViewSearchRowInfo.worker_DoWork(Object sender, DoWorkEventArgs e)
   at System.ComponentModel.BackgroundWorker.OnDoWork(DoWorkEventArgs e)
   at System.ComponentModel.BackgroundWorker.WorkerThreadStart(Object argument)

-----

InvalidOperationException: Failed to compare two elements in the array. ---> NullReferenceException: Object reference not set to an instance of an object.
   at Telerik.WinControls.UI.GridViewRowInfoComparer.CompareRows(GridViewRowInfo x, GridViewRowInfo y, SortDescriptorCollection context)
   at System.Collections.Generic.ArraySortHelper`1.InternalBinarySearch(T[] array, Int32 index, Int32 length, T value, IComparer`1 comparer)
   at System.Collections.Generic.ArraySortHelper`1.BinarySearch(T[] array, Int32 index, Int32 length, T value, IComparer`1 comparer)


   --- End of inner exception stack trace ---
   at System.Collections.Generic.ArraySortHelper`1.BinarySearch(T[] array, Int32 index, Int32 length, T value, IComparer`1 comparer)
   at System.Collections.Generic.List`1.BinarySearch(Int32 index, Int32 count, T item, IComparer`1 comparer)
   at Telerik.Collections.Generic.HybridIndex`1.PerformWithQuickSort()
   at Telerik.Collections.Generic.HybridIndex`1.get_Items()
   at Telerik.Collections.Generic.Index`1.GetEnumerator()
   at Telerik.WinControls.Data.GroupBuilder`1.Perform(IReadOnlyCollection`1 items, Int32 level, Group`1 parent)
   at Telerik.WinControls.Data.GroupBuilder`1.get_Groups()
   at Telerik.WinControls.UI.GridViewInfo.Refresh()
   at Telerik.WinControls.UI.GridViewInfo.get_ChildRows()
   at Telerik.WinControls.UI.ViewInfoTraverser.SetCollectionForStage(Boolean initializeCollection)
   at Telerik.WinControls.UI.ViewInfoTraverser.ChangeCollectionForward()
   at Telerik.WinControls.UI.ViewInfoTraverser.MoveNextCore()
   at Telerik.WinControls.UI.ViewInfoTraverser.MoveNext()
   at Telerik.WinControls.UI.GridTraverser.MoveNextCore()
   at Telerik.WinControls.UI.GridTraverser.MoveNext()
   at Telerik.WinControls.UI.BaseGridNavigator.NavigateToRow(GridViewRowInfo row, Boolean select)
   at Telerik.WinControls.UI.BaseGridNavigator.ProcessViewChangedEvent(GridViewEvent eventData)
   at Telerik.WinControls.UI.BaseGridNavigator.ProcessEventCore(GridViewEvent eventData)
   at Telerik.WinControls.UI.GridViewEventProcessEntity.ProcessCollection(GridViewEvent gridEvent, PriorityWeakReferenceList list, GridEventProcessMode processMode)
   at Telerik.WinControls.UI.GridViewEventProcessEntity.ProcessEvent(GridViewEvent gridEvent)
   at Telerik.WinControls.UI.GridViewSynchronizationService.NotifyListeners(GridViewEvent gridEvent)
   at Telerik.WinControls.UI.GridViewSynchronizationService.FlushEvents()
   at Telerik.WinControls.UI.GridViewSynchronizationService.DispatchEvent(GridViewEvent gridEvent)
   at Telerik.WinControls.UI.GridViewSynchronizationService.DispatchEvent(GridViewTemplate template, GridViewEvent eventData, Boolean postUI)
   at Telerik.WinControls.UI.GridViewTemplate.DispatchDataViewChangedEvent(Object sender, DataViewChangedEventArgs args)
   at Telerik.WinControls.UI.GridViewTemplate.OnViewChanged(Object sender, DataViewChangedEventArgs e)
   at Telerik.WinControls.UI.MasterGridViewTemplate.OnViewChanged(Object sender, DataViewChangedEventArgs e)
   at Telerik.WinControls.Data.RadDataView`1.RebuildData(Boolean notify)
   at Telerik.WinControls.Data.RadDataView`1.OnNotifyPropertyChanged(PropertyChangedEventArgs e)
   at Telerik.WinControls.Data.RadCollectionView`1.OnNotifyPropertyChanged(String propertyName)
   at Telerik.WinControls.UI.GridViewSortDescriptorCollection.OnCollectionChanged(NotifyCollectionChangedEventArgs args)
   at System.ComponentModel.PropertyChangedEventHandler.Invoke(Object sender, PropertyChangedEventArgs e)
   at Telerik.WinControls.Data.SortDescriptor.set_Direction(ListSortDirection value)
   at Telerik.WinControls.UI.GridViewColumn.Sort(RadSortOrder sortOrder, Boolean multiSortMode)
   at Telerik.WinControls.UI.GridHeaderCellElement.Sort(RadSortOrder sortOrder)
   at Telerik.WinControls.UI.GridHeaderRowBehavior.OnMouseUp(MouseEventArgs e)
   at Telerik.WinControls.UI.BaseGridBehavior.OnMouseUp(MouseEventArgs e)
   at Telerik.WinControls.UI.RadGridView.OnMouseUp(MouseEventArgs e)
   at System.Windows.Forms.Control.WmMouseUp(Message& m, MouseButtons button, Int32 clicks)
   at System.Windows.Forms.Control.WndProc(Message& m)
   at Telerik.WinControls.RadControl.WndProc(Message& m)
   at Telerik.WinControls.UI.RadGridView.WndProc(Message& m)
   at System.Windows.Forms.NativeWindow.Callback(IntPtr hWnd, Int32 msg, IntPtr wparam, IntPtr lparam)

------

InvalidOperationException: Collection was modified; enumeration operation may not execute.
   at System.ThrowHelper.ThrowInvalidOperationException(ExceptionResource resource)
   at System.Collections.Generic.List`1.Enumerator.MoveNextRare()
   at System.Collections.Generic.List`1.Enumerator.MoveNext()
   at Telerik.WinControls.UI.DataGroup.<GetEnumerator>d__0.MoveNext()
[...]
   at System.Collections.Generic.List`1..ctor(IEnumerable`1 collection)
   at System.Linq.Enumerable.ToList[TSource](IEnumerable`1 source)
   at Alto.Client.Controls.Dispatch.DispatchResources.DeliveryPointFilterManager.get_DeliveryPointsVisible() in d:\Builds\45153\Alto\Alto.Prod\src\Alto\Alto.Client\Controls\Dispatch\DispatchResources\DeliveryPointFilterManager.cs:line 38
   at Alto.Client.Controls.Dispatch.DispatchResources.UcDeliveryPoint.get_Title() in d:\Builds\45153\Alto\Alto.Prod\src\Alto\Alto.Client\Controls\Dispatch\DispatchResources\UcDeliveryPoint.cs:line 1520
   at Alto.Client.Controls.Dispatch.DispatchResources.UcDeliveryPoint.updatePanelTitle() in d:\Builds\45153\Alto\Alto.Prod\src\Alto\Alto.Client\Controls\Dispatch\DispatchResources\UcDeliveryPoint.cs:line 543
   at Alto.Client.Controls.Dispatch.DispatchResources.UcDeliveryPoint.onFilterChanged(Object sender, GridViewCollectionChangedEventArgs e) in d:\Builds\45153\Alto\Alto.Prod\src\Alto\Alto.Client\Controls\Dispatch\DispatchResources\UcDeliveryPoint.cs:line 547
   at Telerik.WinControls.UI.GridViewCollectionChangedEventHandler.Invoke(Object sender, GridViewCollectionChangedEventArgs e)
   at Telerik.WinControls.UI.RadGridView.OnFilterChanged(Object sender, GridViewCollectionChangedEventArgs e)
   at Telerik.WinControls.UI.EventDispatcher.RaiseEvent[T](Object eventKey, Object sender, T args)
   at Telerik.WinControls.UI.GridViewFilterDescriptorCollection.OnCollectionChanged(NotifyCollectionChangedEventArgs args)
   at Telerik.Collections.Generic.NotifyCollection`1.InsertItem(Int32 index, T item)
   at Telerik.WinControls.UI.GridViewFilterDescriptorCollection.InsertItem(Int32 index, FilterDescriptor item)
   at System.Collections.ObjectModel.Collection`1.Add(T item)
   at Telerik.WinControls.UI.GridViewDataColumn.SetFilterDescriptor(FilterDescriptor value)
   at Telerik.WinControls.UI.GridHeaderCellElement.filterPopup_FilterConfirmed(Object sender, EventArgs e)
   at Telerik.WinControls.UI.BaseFilterPopup.OnFilterConfirmed()
   at Telerik.WinControls.UI.RadListFilterPopup.OnButtonOkClick(EventArgs e)
   at Telerik.WinControls.UI.RadListFilterPopup.ButtonOK_Click(Object sender, EventArgs e)
   at Telerik.WinControls.RadElement.OnClick(EventArgs e)
   at Telerik.WinControls.UI.RadButtonItem.OnClick(EventArgs e)
   at Telerik.WinControls.UI.RadButtonElement.OnClick(EventArgs e)
   at Telerik.WinControls.RadElement.DoClick(EventArgs e)
   at Telerik.WinControls.RadElement.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
   at Telerik.WinControls.RadItem.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
   at Telerik.WinControls.RadElement.RaiseRoutedEvent(RadElement sender, RoutedEventArgs args)
   at Telerik.WinControls.RadElement.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
   at Telerik.WinControls.RadItem.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
   at Telerik.WinControls.RadElement.RaiseRoutedEvent(RadElement sender, RoutedEventArgs args)
   at Telerik.WinControls.RadElement.DoMouseUp(MouseEventArgs e)
   at Telerik.WinControls.ComponentInputBehavior.OnMouseUp(MouseEventArgs e)
   at Telerik.WinControls.RadControl.OnMouseUp(MouseEventArgs e)
   at System.Windows.Forms.Control.WmMouseUp(Message& m, MouseButtons button, Int32 clicks)
   at System.Windows.Forms.Control.WndProc(Message& m)
   at System.Windows.Forms.ScrollableControl.WndProc(Message& m)
   at Telerik.WinControls.RadControl.WndProc(Message& m)
   at Telerik.WinControls.UI.RadPopupControlBase.WndProc(Message& m)
   at System.Windows.Forms.Control.ControlNativeWindow.OnMessage(Message& m)
   at System.Windows.Forms.Control.ControlNativeWindow.WndProc(Message& m)
   at System.Windows.Forms.NativeWindow.Callback(IntPtr hWnd, Int32 msg, IntPtr wparam, IntPtr lparam)

----

InvalidOperationException: Collection was modified; enumeration operation may not execute.
   at System.Collections.Generic.List`1.Enumerator.MoveNextRare()
   at Telerik.WinControls.UI.DataGroup.<GetEnumerator>d__0.MoveNext()
   at Telerik.WinControls.Data.GroupBuilder`1.Perform(IReadOnlyCollection`1 items, Int32 level, Group`1 parent)
   at Telerik.WinControls.Data.DataItemGroup`1.get_Groups()
   at Telerik.WinControls.UI.DataGroup.get_Groups()
   at Telerik.WinControls.UI.GridViewTemplate.InvalidateSummaryRowsCore(DataGroup group, Boolean invalidateChildren)
   at Telerik.WinControls.UI.GridViewTemplate.InvalidateSummaryRowsCore(DataGroup group, Boolean invalidateChildren)
   at Telerik.WinControls.UI.GridViewTemplate.InvalidateGroupSummaryRows(DataGroup group, Boolean invalidateChildren)
   at Telerik.WinControls.UI.GridViewTemplate.RefreshSummaryRowsInGroup(NotifyCollectionChangedEventArgs e)
   at Telerik.WinControls.UI.GridViewTemplate.RefreshAggregates(NotifyCollectionChangedEventArgs e)
   at Telerik.WinControls.UI.MasterGridViewTemplate.OnViewChanged(Object sender, DataViewChangedEventArgs e)
   at Telerik.WinControls.Data.RadDataView`1.RebuildData(Boolean notify)
   at Telerik.WinControls.Data.RadDataView`1.OnNotifyPropertyChanged(PropertyChangedEventArgs e)
   at Telerik.WinControls.Data.RadCollectionView`1.OnNotifyPropertyChanged(String propertyName)
   at Telerik.WinControls.UI.GridViewSortDescriptorCollection.OnCollectionChanged(NotifyCollectionChangedEventArgs args)
   at Telerik.WinControls.UI.GridViewSortDescriptorCollection.RemoveItem(Int32 index)
   at Telerik.WinControls.UI.GridViewColumn.Sort(RadSortOrder sortOrder, Boolean multiSortMode)
   at Telerik.WinControls.UI.GridHeaderCellElement.Sort(RadSortOrder sortOrder)
   at Telerik.WinControls.UI.GridHeaderRowBehavior.OnMouseUp(MouseEventArgs e)
   at Telerik.WinControls.UI.BaseGridBehavior.OnMouseUp(MouseEventArgs e)
   at Telerik.WinControls.UI.RadGridView.OnMouseUp(MouseEventArgs e)
   at System.Windows.Forms.Control.WmMouseUp(Message& m, MouseButtons button, Int32 clicks)
   at System.Windows.Forms.Control.WndProc(Message& m)
   at Telerik.WinControls.RadControl.WndProc(Message& m)
   at Telerik.WinControls.UI.RadGridView.WndProc(Message& m)
   at System.Windows.Forms.NativeWindow.Callback(IntPtr hWnd, Int32 msg, IntPtr wparam, IntPtr lparam)

Use attached to reproduce.

This is not an issue. Performing Begin/End update disposes of all elements along with the globally declared item. You need to check if the item is disposed of:
void ContextMenuOpening(object sender, ContextMenuOpeningEventArgs e)
{
    if (menuItem.IsDisposed)
    {
        menuItem = new RadMenuItem();
        menuItem.Text = "Custom menu item";
        menuItem.Click += menuItem_Click;
    }
    e.ContextMenu.Items.Add(menuItem);
}

Hi Mostafa,

The end users can copy a single cell even when the SelectionMode is set to FullRowSelect via the ContextMenu when opening it on any of the data cells. If the context menu is opened on the row header they will select the whole row. Please check the attached video: radgridview-context-menu-behavior.gif.

If you would like to copy a single cell using the Ctrl-C command and have the grid setup in FullRowSelect mode please check the attached project featuring a solution. I am also attaching a video showing the result using the custom implementation in the project: radgridview-full-row-ctrl-c.gif

Create a grid with more than 20 columns and add 5K rows for example. Maximize the form and try to scroll with mouse wheel. You will notice that the scrolling performance is worse compared to the normal state of the form with less visible visual elements.

Workaround: this.radGridView1.EnableFastScrolling = true; and use the scrollbar's thumb

Second workaround: use paging:  https://docs.telerik.com/devtools/winforms/gridview/paging/overview Thus, you will display as many rows as possible to display on the screen per page. Instead of scrolling, you will navigate through pages.

To reproduce: please refer to the attached sample project. 

Workaround:   this.radGridView1.TableElement.ScrollToRow(this.radGridView1.RowCount-1);

To reproduce: please open the attached sample project and follow the steps illustrated in the attached gif file.

Workaround: 
1. You still can scroll while dragging a row by using the mouse wheel.

2. Use the grid in unbound mode and set the AllowRowReorder property to true instead of using a custom RadDragDropService.

3. Use a custom drag and drop service:

public class CustomDragDropService : RadGridViewDragDropService
{
    public CustomDragDropService(RadGridViewElement gridViewElement) : base(gridViewElement)
    {
    }

    public override string Name
    {
        get
        {
            return typeof(RadGridViewDragDropService).Name;
        }
    }

    protected override void HandleMouseMove(System.Drawing.Point mousePosition)
    {
        base.HandleMouseMove(mousePosition);
        System.Drawing.Point location = this.GridViewElement.ElementTree.Control.PointToClient(Control.MousePosition);
        GridTableElement tableElement = this.GetTableElementAtPoint(location);

        ISupportDrag supportDrag = this.Context as ISupportDrag;
        object dataContext = supportDrag.GetDataContext();

        if (this.AllowAutoScrollRowsWhileDragging && dataContext == null)
        {
            ScrollRows(tableElement, location);
        }
    }

    private void ScrollRows(GridTableElement tableElement, System.Drawing.Point location)
    {
        ScrollableRowsContainerElement scrollableRows = tableElement.ViewElement.ScrollableRows;
        RadScrollBarElement vScrollbar = GetVeritcalScrollbar(tableElement);
        System.Drawing.Rectangle containerBounds = scrollableRows.ControlBoundingRectangle;

        if (containerBounds.Contains(location) ||
            location.X < containerBounds.X ||
            location.X > containerBounds.Right)
        {
            return;
        }

        int delta = 0;

        if (location.Y > containerBounds.Bottom)
        {
            delta = location.Y - containerBounds.Bottom;
        }
        else if (location.Y < containerBounds.Y)
        {
            delta = location.Y - containerBounds.Y;
        }

        if (delta != 0 && vScrollbar.Visibility == ElementVisibility.Visible)
        {
            vScrollbar.Value = ClampValue(vScrollbar.Value + delta,
                vScrollbar.Minimum,
                vScrollbar.Maximum - vScrollbar.LargeChange + 1);
        }
    }

    private int ClampValue(int value, int minimum, int maximum)
    {
        if (value < minimum)
        {
            return minimum;
        }
        if (maximum > 0 && value > maximum)
        {
            return maximum;
        }
        return value;
    }

    private RadScrollBarElement GetVeritcalScrollbar(GridTableElement tableElement)
    {
        if (GridViewElement.UseScrollbarsInHierarchy)
        {
            return tableElement.VScrollBar;
        }
        return GridViewElement.TableElement.VScrollBar;
    }
}

public RadForm1()
{
    InitializeComponent();
    CustomDragDropService customService = new CustomDragDropService(radGridView1.GridViewElement);
    radGridView1.GridViewElement.RegisterService(customService);
}

To reproduce
- Start the attached project press "Add in code"  then "Save"
- The row is still not added to the underlying data table. 

Workaround:
TryCast(Me.radGridView1.Rows.Last().DataBoundItem, IEditableObject).EndEdit()

To reproduce: please refer to the attached gif file and sample project.

Workaround: when you set the DrawFill property to true, specify the BackColor to the desired one and reset for the rest of the cells.

private void radGridView1_CellFormatting(object sender, Telerik.WinControls.UI.CellFormattingEventArgs e)
{
    if (e.Column.Name == "ProductName" && e.Row is GridViewDataRowInfo)
    {
        if (e.CellElement.Value.ToString().Contains("C"))
        {
            e.CellElement.DrawFill = true;
            e.CellElement.BackColor = Color.Yellow;
            e.CellElement.GradientStyle = GradientStyles.Solid;
            e.CellElement.ForeColor = Color.OliveDrab;
        }
        else
        { 
            e.CellElement.ResetValue(LightVisualElement.DrawFillProperty, ValueResetFlags.Local);
            e.CellElement.ResetValue(LightVisualElement.GradientStyleProperty, ValueResetFlags.Local);
            e.CellElement.ResetValue(LightVisualElement.ForeColorProperty, ValueResetFlags.Local);  
            e.CellElement.ResetValue(LightVisualElement.BackColorProperty, ValueResetFlags.Local);  
        }
    }
    else
    { 
        e.CellElement.ResetValue(LightVisualElement.DrawFillProperty, ValueResetFlags.Local);
        e.CellElement.ResetValue(LightVisualElement.GradientStyleProperty, ValueResetFlags.Local);
        e.CellElement.ResetValue(LightVisualElement.ForeColorProperty, ValueResetFlags.Local);    
        e.CellElement.ResetValue(LightVisualElement.BackColorProperty, ValueResetFlags.Local);  
    }
}

To reproduce: please refer to the attached sample project and gif file illustrating the behavior.

Workaround: in order to cancel adding of the new row, you can call the MasterView.TableAddNewRow.CancelAddNewRow method:

private void radGridView1_UserAddingRow(object sender, Telerik.WinControls.UI.GridViewRowCancelEventArgs e)
{
    e.Cancel = true;
    this.radGridView1.MasterView.TableAddNewRow.CancelAddNewRow(); 
    int index = this.radGridView1.Rows.Count;
    this.radGridView1.Rows.Add(index, "Row" + index);
}

Hello,

we have a RadGridview with a number column and a activated filter for this Grid. 
If we want to filter data by the value "123" the input in the filter textBox is shown as "321.00" (right-to-left).

This is no problem by columns with text values. And at the line for a new data row the input is correct, too.

To reproduce, add menu item in the filtering context menu and upon click, set it as checked. Note that the filtering cell text should also take the custom menu item text or there should be an approach to set it.
Workaround: uncomment the commented code below.

protected override void OnLoad(EventArgs e)
        {
            base.OnLoad(e);

            AddGrid();

            DataTable dt = new DataTable();
            dt.Columns.Add("Id", typeof(int));
            dt.Columns.Add("Name", typeof(string));

            for (int i = 0; i < 5; i++)
            {
                dt.Rows.Add(i, "Item" + i);
            }
            dt.Rows.Add(5, null);
            dt.Rows.Add(6, "");

            radGridView1.ShowHeaderCellButtons = true;
            this.radGridView1.DataSource = dt;
            this.radGridView1.AutoSizeColumnsMode = Telerik.WinControls.UI.GridViewAutoSizeColumnsMode.Fill;
            this.radGridView1.EnableFiltering = true;
            this.radGridView1.EnableCustomFiltering = true;
            //radGridView1.ContextMenuOpening += radGridView1_ContextMenuOpening;
        }

        private void radGridView1_ContextMenuOpening(object sender, Telerik.WinControls.UI.ContextMenuOpeningEventArgs e)
        {
            GridFilterCellElement filterCell = e.ContextMenuProvider as GridFilterCellElement;
            GridViewDataColumn dataCol = (GridViewDataColumn)filterCell.ColumnInfo;
            if (filterCell != null)
            {
                if (filterCell.ColumnInfo.Name == "Name")
                {
                    RadMenuItem isNullMenuItem = new RadMenuItem();
                    isNullMenuItem.Click += customMenuItem_Click;
                    isNullMenuItem.Text = "My IsNull";
                    isNullMenuItem.Tag = filterCell.ColumnInfo.Name;
                    e.ContextMenu.Items.Add(isNullMenuItem);

                    RadMenuItem isNotNullMenuItem = new RadMenuItem();
                    isNotNullMenuItem.Click += customMenuItem_Click;
                    isNotNullMenuItem.Text = "My IsNotNull";
                    isNotNullMenuItem.Tag = filterCell.ColumnInfo.Name;
                    e.ContextMenu.Items.Add(isNotNullMenuItem);

                    bool isCustomFilter = (dataCol.FilterDescriptor != null &&
                        dataCol.FilterDescriptor is CompositeFilterDescriptor &&
                        dataCol.FilterDescriptor.Expression.Contains("NULL"));

                    foreach (RadMenuItem item in e.ContextMenu.Items)
                    {
                        if (item.Text == "Is null" || item.Text == "Is not null")
                        {
                            item.Visibility = Telerik.WinControls.ElementVisibility.Collapsed;
                        }
                        //if (isCustomFilter)
                        //{
                        //    item.IsChecked = false;
                        //}
                    }
                    //if (isCustomFilter)
                    //{
                    //    if (((CompositeFilterDescriptor)dataCol.FilterDescriptor).LogicalOperator == FilterLogicalOperator.And)
                    //    {
                    //        isNotNullMenuItem.IsChecked = true;
                    //    }
                    //    else
                    //    {
                    //        isNullMenuItem.IsChecked = true;
                    //    }
                    //}
                }
            }
        }

        private void customMenuItem_Click(object sender, EventArgs e)
        {
            RadMenuItem clickedItem = (RadMenuItem)sender;
            string columnName = clickedItem.Tag.ToString();
            radGridView1.Columns[columnName].FilterDescriptor = null;

            FilterOperator filterOperator = clickedItem.Text.Contains("Not") ? FilterOperator.IsNotEqualTo : FilterOperator.IsEqualTo;
            FilterLogicalOperator logicalOperator = clickedItem.Text.Contains("Not") ? FilterLogicalOperator.And : FilterLogicalOperator.Or;

            CompositeFilterDescriptor compositeFilter = new CompositeFilterDescriptor();
            compositeFilter.FilterDescriptors.Add(new FilterDescriptor(columnName, filterOperator, ""));
            compositeFilter.FilterDescriptors.Add(new FilterDescriptor(columnName, filterOperator, null));
            compositeFilter.LogicalOperator = logicalOperator;
            compositeFilter.IsFilterEditor = true;
            this.radGridView1.FilterDescriptors.Add(compositeFilter);

            clickedItem.IsChecked = true;
        }

Steps to reproduce:

1. Add a CompositeFilterDescriptor programmatically as it is demonstrated in the following help article: http://docs.telerik.com/devtools/winforms/gridview/filtering/setting-filters-programmatically-(composite-descriptors)
2. Save the layout.
3. Load the layout.

Workaround: specify the PropertyName property for the CompositeFilterDescriptor.

Please refer to the attached screenshot.

Workaround:

public Form1()
{
    InitializeComponent();

    DataTable dt = new DataTable();
    dt.Columns.Add("Id");
    dt.Columns.Add("Name");
    for (int i = 0; i < 5; i++)
    {
        dt.Rows.Add(i, "Item" + i);
    }

    this.radGridView1.DataSource = dt;
    this.radGridView1.AutoSizeColumnsMode = Telerik.WinControls.UI.GridViewAutoSizeColumnsMode.Fill;

    this.radGridView1.AllowSearchRow = true;
    this.radGridView1.SearchRowPosition = Telerik.WinControls.UI.SystemRowPosition.Bottom;

    this.radGridView1.ViewDefinition = new CustomTableViewDefition();
}

public class CustomTableViewDefition : TableViewDefinition
{
    public override IRowView CreateViewUIElement(GridViewInfo viewInfo)
    {
        return new CustomTableElement();
    }
}

public class CustomTableElement : GridTableElement
{
    protected override RowsContainerElement CreateViewElement()
    {
        return new CustomRowsContainerElement();
    }
}

public class CustomRowsContainerElement : RowsContainerElement
{
    protected override SizeF ArrangeOverride(SizeF finalSize)
    {
        float y = 0;

        this.TopPinnedRows.Arrange(new RectangleF(0, y, finalSize.Width, this.TopPinnedRows.DesiredSize.Height));
        y += this.TopPinnedRows.DesiredSize.Height + ElementSpacing;

        this.ScrollableRows.Arrange(new RectangleF(0, y, finalSize.Width, this.ScrollableRows.DesiredSize.Height));
        y += this.ScrollableRows.DesiredSize.Height + ElementSpacing;

        this.BottomPinnedRows.Arrange(new RectangleF(0, finalSize.Height - this.BottomPinnedRows.DesiredSize.Height,
            finalSize.Width, this.BottomPinnedRows.DesiredSize.Height));

        return finalSize;
    }
}

When you set a RadGridView's SelectionMode to GridViewSelectionMode.CellSelect and then you highlight full rows by using the row header, the SelectedRows collection is empty.  Telerik support informed me this is "as expected" and that I should use "SelectedCells" collection when using the CellSelect Mode.  While this is a decent workaround I don't see why SelectedRows collection can't be filled when the entire row is actually highlighted.  

To reproduce: use the following code snippet and enter in the filter row one of the row values as it is shown in the screenshot:

this.radGridView1.EnableFiltering = true;
GridViewDateTimeColumn dateTimeColumn = new GridViewDateTimeColumn("DateTimeColumn");  
dateTimeColumn.Format = DateTimePickerFormat.Custom;
dateTimeColumn.CustomFormat = "dd/MM/yyyy HH:mm:ss";
radGridView1.MasterTemplate.Columns.Add(dateTimeColumn);
this.radGridView1.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill;

for (int i = 0; i < 10; i++)
{
    this.radGridView1.Rows.Add(DateTime.Now.AddDays(i));
}

Workaround: custom filtering: http://docs.telerik.com/devtools/winforms/gridview/filtering/custom-filtering