Steps to reproduce:

1. Add a CompositeFilterDescriptor programmatically as it is demonstrated in the following help article: http://docs.telerik.com/devtools/winforms/gridview/filtering/setting-filters-programmatically-(composite-descriptors)
2. Save the layout.
3. Load the layout.

Use attached project to reproduce.

Workaround:
Seth te PropertyName to a valid column name.

To reproduce:

DataTable dt = new DataTable();
dt.Columns.Add("Id", typeof(int));
dt.Columns.Add("Name", typeof(string));
dt.Columns.Add("IsActive", typeof(bool));

dt.Rows.Add(1, "Parent1", false);
dt.Rows.Add(2, "Parent2", false);

this.radGridView1.DataSource = dt;
((GridViewCheckBoxColumn)this.radGridView1.MasterTemplate.Columns["IsActive"]).EnableHeaderCheckBox = true;
this.radGridView1.AutoSizeColumnsMode = Telerik.WinControls.UI.GridViewAutoSizeColumnsMode.Fill;

DataTable childDataTable = new DataTable();
childDataTable.Columns.Add("Id", typeof(int));
childDataTable.Columns.Add("Title", typeof(string));
childDataTable.Columns.Add("ParentId", typeof(int));            
childDataTable.Columns.Add("IsValid", typeof(bool));
childDataTable.Rows.Add(1, "Child 1", 1, false);
childDataTable.Rows.Add(2, "Child 1", 1, false);
childDataTable.Rows.Add(3, "Child 2", 2, false);
childDataTable.Rows.Add(4, "Child 2", 2, false);

GridViewTemplate template = new GridViewTemplate();
template.DataSource = childDataTable;            
((GridViewCheckBoxColumn)template.Columns["IsValid"]).EnableHeaderCheckBox = true;
radGridView1.MasterTemplate.Templates.Add(template);
template.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill;

GridViewRelation relation = new GridViewRelation(radGridView1.MasterTemplate);
relation.ChildTemplate = template;
relation.RelationName = "MasterDeatial";
relation.ParentColumnNames.Add("Id");
relation.ChildColumnNames.Add("ParentId");
radGridView1.Relations.Add(relation);

The GridViewCheckBoxColumn.EditMode property controls when the value of the editor will be submitted to the cell. By default, the value is OnValidate and the value will be submitted only when the current cell changes, the grid looses focus or the active editor is closed by pressing Enter. If you set the EditMode property to OnValueChange it will submit the value immediately after the editor value changes. Please refer to the attached gif files illustrating the difference between the two modes.

To reproduce: if you set the GridViewCheckBoxColumn.EnableHeaderCheckBox property to true, the cell value is always submitted immediately after toggle/untoggle the checkbox without considering that EditMode.OnValidate is used.

How to reproduce: 
 public partial class Form1 : Form
 {
     public Form1()
     {
         InitializeComponent();
         GridViewDecimalColumn decimalColumn = new GridViewDecimalColumn();
         decimalColumn.Name = "DecimalColumn";
         decimalColumn.HeaderText = "DecimalColumn";
         this.radGridView1.MasterTemplate.Columns.Add(decimalColumn);

         GridViewTextBoxColumn textBoxColumn = new GridViewTextBoxColumn();
         textBoxColumn.Name = "TextBoxColumn";
         textBoxColumn.HeaderText = "TextBoxColumn";
         this.radGridView1.MasterTemplate.Columns.Add(textBoxColumn);

         GridViewDateTimeColumn dateTimeColumn = new GridViewDateTimeColumn();
         dateTimeColumn.Name = "DateTimeColumn";
         dateTimeColumn.HeaderText = "DateTimeColumn";
         this.radGridView1.MasterTemplate.Columns.Add(dateTimeColumn);
     }
 }

Workaround: this.radGridView1.MasterView.TableAddNewRow.MinHeight = 30;

When the EnableHeaderCheckBox property is set to true, whenever the checkbox is clicked in the new row, a new row is actually added to the grid before any other modifications are made. This can be replicated in the attached sample project. Run it and click the checkbox in the new row several times. Multiple rows are added.  

Workaround: cancel the RadGridView.UserAddingRow until all the required fields are filled.

To reproduce: 

public Form1()
{
    InitializeComponent();
     
    DataTable dt = new DataTable();
    dt.Columns.Add("Id");
    dt.Columns.Add("Name");
    for (int i = 0; i < 1; i++)
    {
        dt.Rows.Add(i, "Item");
    }
    this.radGridView1.DataSource = dt;
    this.radGridView1.SelectionMode = GridViewSelectionMode.FullRowSelect;
    this.radGridView1.ClipboardCopyMode = Telerik.WinControls.UI.GridViewClipboardCopyMode.EnableAlwaysIncludeHeaderText;
    this.radGridView1.MultiSelect = true; 
}

private void button1_Click(object sender, EventArgs e)
{
    this.radGridView1.SelectAll();
    this.radGridView1.Copy();
}

If you click the button, you will notice that only one cell is copied. However, if you add 2 and more rows, the whole grid content will be copied to the clipboard.

Workaround: use the BeginRowCopy/EndRowCopy methods.

private void button1_Click(object sender, EventArgs e)
{
    this.radGridView1.SelectAll();
    this.radGridView1.MasterTemplate.BeginRowCopy();
    this.radGridView1.Copy();
    this.radGridView1.MasterTemplate.EndRowCopy();
}

To reproduce:
- Add several columns including combo-box columns to a grid. 
- Add one row and upon a button click, change the data source of the combo column.

Workaround: 

Seth the following field to null prior changing the data source: 

    GetType(GridViewComboBoxColumn).GetField("nullBoundItem", Reflection.BindingFlags.Instance Or Reflection.BindingFlags.NonPublic).SetValue(combo, Nothing)
    combo.DataSource = dt

To reproduce:

Sub New()
     
    InitializeComponent()

    Dim dt1 As New DataTable
    dt1.Columns.Add("Id", GetType(Integer))
    dt1.Columns.Add("Name", GetType(String))
    For index = 1 To 20
        dt1.Rows.Add(index, "Parent" & index)
    Next
    Me.RadGridView1.MasterTemplate.DataSource = dt1
    Me.RadGridView1.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill

    Dim dt2 As New DataTable
    dt2.Columns.Add("Id", GetType(Integer))
    dt2.Columns.Add("Name", GetType(String))
    dt2.Columns.Add("ParentId", GetType(Integer))

    Dim dt3 As New DataTable
    dt3.Columns.Add("Id", GetType(Integer))
    dt3.Columns.Add("Name", GetType(String))
    dt3.Columns.Add("ParentId", GetType(Integer))
    For index = 1 To 20
        If index Mod 2 = 0 Then
            dt2.Rows.Add(index, "Child1." & index, index)
            If index Mod 4 = 0 Then
                dt3.Rows.Add(index, "Child2." & index, index)
            End If
        ElseIf index Mod 3 = 0 Then
            dt3.Rows.Add(index, "Child2." & index, index)
        Else
            dt3.Rows.Add(index, "Child2." & index, index)
        End If

    Next

    Dim template As New GridViewTemplate()
    template.DataSource = dt2
    template.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill
    RadGridView1.MasterTemplate.Templates.Add(template)

    Dim relation As New GridViewRelation(RadGridView1.MasterTemplate)
    relation.ChildTemplate = template
    relation.RelationName = "FirstChild"
    relation.ParentColumnNames.Add("Id")
    relation.ChildColumnNames.Add("ParentId")
    RadGridView1.Relations.Add(relation)

    Dim template2 As New GridViewTemplate()
    template2.DataSource = dt3
    template2.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill
    RadGridView1.MasterTemplate.Templates.Add(template2)

    Dim relation2 As New GridViewRelation(RadGridView1.MasterTemplate)
    relation2.ChildTemplate = template2
    relation2.RelationName = "SecondChild"
    relation2.ParentColumnNames.Add("Id")
    relation2.ChildColumnNames.Add("ParentId")
    RadGridView1.Relations.Add(relation2)

    AddHandler Me.RadGridView1.ChildViewExpanding, AddressOf ChildViewExpanding
End Sub

Private Sub RadGridView1_ViewCellFormatting(sender As Object, e As Telerik.WinControls.UI.CellFormattingEventArgs) _
Handles RadGridView1.ViewCellFormatting
    Dim cell As GridDetailViewCellElement = TryCast(e.CellElement, GridDetailViewCellElement)
    Dim expanderCell As GridGroupExpanderCellElement = TryCast(e.CellElement, GridGroupExpanderCellElement)
    If expanderCell IsNot Nothing AndAlso TypeOf e.CellElement.RowElement Is GridDataRowElement Then
        Dim hierarchyRow As GridViewHierarchyRowInfo = DirectCast(expanderCell.RowInfo, GridViewHierarchyRowInfo)
        If Not IsExpandable(hierarchyRow) Then
            expanderCell.Expander.Visibility = Telerik.WinControls.ElementVisibility.Hidden
        Else
            expanderCell.Expander.Visibility = Telerik.WinControls.ElementVisibility.Visible
        End If
    ElseIf cell IsNot Nothing Then
        Dim hierarchyRow As GridViewHierarchyRowInfo = DirectCast(DirectCast(cell.RowInfo, GridViewDetailsRowInfo).Owner,  _
        GridViewHierarchyRowInfo)
        For i As Integer = 0 To cell.PageViewElement.Items.Count - 1
            Dim item As RadPageViewItem = cell.PageViewElement.Items(i)
            Dim viewInfo As GridViewInfo = hierarchyRow.Views(i)
            item.Text = "Child Template " & i
            If viewInfo.ChildRows.Count = 0 Then
                If i = 0 AndAlso i < cell.PageViewElement.Items.Count - 1 Then
                    cell.PageViewElement.Items(i + 1).IsSelected = True
                End If
                item.Visibility = Telerik.WinControls.ElementVisibility.Hidden
            Else
                item.Visibility = Telerik.WinControls.ElementVisibility.Visible
            End If
        Next
    End If
End Sub

Private Function IsExpandable(hierarchyRow As GridViewHierarchyRowInfo) As Boolean
    For Each view As GridViewInfo In hierarchyRow.Views
        If view.ChildRows.Count > 0 Then
            Return True
        End If
    Next
    Return False
End Function

Workaround:

AddHandler Me.RadGridView1.ChildViewExpanding, AddressOf RadGridView1_ChildViewExpanding 
AddHandler Me.RadGridView1.MouseDown, AddressOf RadGridView_MouseDown

Private Sub RadGridView1_ChildViewExpanding(sender As Object, e As ChildViewExpandingEventArgs)
    If lastClicked IsNot Nothing AndAlso e.ParentRow.Equals(lastClicked) Then
        e.Cancel = False
    Else
        e.Cancel = True
    End If

End Sub

Dim lastClicked As GridViewRowInfo

Private Sub RadGridView_MouseDown(sender As Object, e As MouseEventArgs)
    Dim expander As GridExpanderItem = TryCast(Me.RadGridView1.ElementTree.GetElementAtPoint(e.Location), GridExpanderItem)
    If expander IsNot Nothing Then
        lastClicked = DirectCast(expander.Parent, GridGroupExpanderCellElement).RowInfo 
    End If 
End Sub

To reproduce:
- Add GridViewTextBoxColumn and set the MaxLength property.
- Paste in data row while the is not in edit mode.

Workaround:
private void RadGridView1_Pasting(object sender, Telerik.WinControls.UI.GridViewClipboardEventArgs e)
{
    if (radGridView1.CurrentColumn.Name == "column1")
    {
        GridViewTextBoxColumn col = new GridViewTextBoxColumn();
        var lenght = col.MaxLength;
        if (Clipboard.ContainsData(DataFormats.Text))
        {
            e.Cancel = true;
            string data = Clipboard.GetData(DataFormats.Text).ToString();
            radGridView1.CurrentCell.Value = data.Substring(0, lenght);
        }
    }
}

 

To reproduce:

Sub New()
     
    InitializeComponent()

    Dim dt As New DataTable
    dt.Columns.Add("Id", GetType(Integer))
    dt.Columns.Add("Name", GetType(String))
    dt.Columns.Add("Description", GetType(String))

    For index = 1 To 5
        dt.Rows.Add(index, "Item" & index, "Description" & index)
    Next
    Me.RadGridView1.DataSource = dt
    Me.RadGridView1.AutoSizeColumnsMode = Telerik.WinControls.UI.GridViewAutoSizeColumnsMode.Fill
    
    AddHandler Me.RadGridView1.UserAddingRow, AddressOf UserAddingRow

End Sub

Private Sub UserAddingRow(sender As Object, e As Telerik.WinControls.UI.GridViewRowCancelEventArgs)
    Me.RadGridView1.MasterView.TableAddNewRow.ErrorText = ""
    If String.IsNullOrEmpty(e.Rows(0).Cells(0).Value) Then
        e.Cancel = True
        Me.RadGridView1.MasterView.TableAddNewRow.ErrorText = "Empty value is not allowed!"
    End If
End Sub

1. Click the new row and enter a value in the last cell. 
2. Click outside the new row, e.g. click on a data row. The UserAddingRow event is canceled and the new row remains current. 
3. Click a data row again without any modification on the new row. The new row is not current anymore. 
4. However, you perform step 1and 2 but instead of clicking a data row, the user clicks a header cell, the new row is not current from the first time. It is necessary to forbid the user to exit the new row until the validation passes or the new row is canceled by pressing Enter.

Workaround:  use the CellValidating/RowValidating event for validating.

Workaround: create a custom GridDetailViewCellElement
Public Class Form1
    Sub New()

        InitializeComponent()

        AddHandler dgvPatients.CreateCell, AddressOf dgvPatients_CreateCell

    End Sub

    Private Sub dgvPatients_CreateCell(sender As Object, e As GridViewCreateCellEventArgs)
        If e.CellType = GetType(GridDetailViewCellElement) Then
            e.CellElement = New MyGridDetailViewCellElement(e.Column, e.Row)
        End If
    End Sub

End Class

Public Class MyGridDetailViewCellElement
    Inherits GridDetailViewCellElement

    Sub New(column As GridViewColumn, rowElement As GridRowElement)
        MyBase.New(column, rowElement)
    End Sub

    Public Overrides Sub UpdateTabItemsVisibility()
        If Me.DetailsRow Is Nothing Then
            Return
        End If

        MyBase.UpdateTabItemsVisibility()
    End Sub

End Class

To reproduce:

GridViewTextBoxColumn textBoxColumn1 = new GridViewTextBoxColumn("Col 1");
textBoxColumn1.FieldName = "col1";
radGridView1.MasterTemplate.Columns.Add(textBoxColumn1);
GridViewTextBoxColumn textBoxColumn2 = new GridViewTextBoxColumn("Col 2");
textBoxColumn2.FieldName = "col2";
textBoxColumn2.FormatString = "{0:d}"; 
radGridView1.MasterTemplate.Columns.Add(textBoxColumn2);
radGridView1.AutoSizeColumnsMode = GridViewAutoSizeColumnsMode.Fill;

DataTable dt = new DataTable();
dt.Columns.Add("col1", typeof(string));
dt.Columns.Add("col2", typeof(DateTime));
for (int i = 0; i < 10; i++)
{
    dt.Rows.Add("Item" + i, DateTime.Now.AddDays(i)); 
}
this.radGridView1.AutoGenerateColumns = false;
this.radGridView1.DataSource = dt;

Right click the row header cell and select Copy. The  following exception occurs although we don't have a GridViewDateTimeColumn : System.InvalidCastException was unhandled
  HResult=-2147467262
  Message=Unable to cast object of type 'Telerik.WinControls.UI.GridViewTextBoxColumn' to type 'Telerik.WinControls.UI.GridViewDateTimeColumn'.
  Source=Telerik.WinControls.GridView
  StackTrace:
       at Telerik.WinControls.UI.MasterGridViewTemplate.CopyRows(String format, Boolean cut, Boolean cutOperation, StringBuilder content)
       at Telerik.WinControls.UI.MasterGridViewTemplate.ProcessContent(String format, Boolean cut, Boolean cutOperation)
       at Telerik.WinControls.UI.MasterGridViewTemplate.CopyContent(Boolean cut)
       at Telerik.WinControls.UI.MasterGridViewTemplate.Copy()
       at Telerik.WinControls.UI.GridDataRowElement.copyItem_Click(Object sender, EventArgs e)
       at Telerik.WinControls.RadElement.OnClick(EventArgs e)
       at Telerik.WinControls.UI.RadButtonItem.OnClick(EventArgs e)
       at Telerik.WinControls.UI.RadMenuItem.OnClick(EventArgs e)
       at Telerik.WinControls.RadElement.DoClick(EventArgs e)
       at Telerik.WinControls.RadElement.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
       at Telerik.WinControls.RadItem.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
       at Telerik.WinControls.RadElement.RaiseRoutedEvent(RadElement sender, RoutedEventArgs args)
       at Telerik.WinControls.RadElement.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
       at Telerik.WinControls.RadItem.RaiseBubbleEvent(RadElement sender, RoutedEventArgs args)
       at Telerik.WinControls.RadElement.RaiseRoutedEvent(RadElement sender, RoutedEventArgs args)
       at Telerik.WinControls.RadElement.DoMouseUp(MouseEventArgs e)
       at Telerik.WinControls.ComponentInputBehavior.OnMouseUp(MouseEventArgs e)
       at Telerik.WinControls.RadControl.OnMouseUp(MouseEventArgs e)
       at System.Windows.Forms.Control.WmMouseUp(Message& m, MouseButtons button, Int32 clicks)
       at System.Windows.Forms.Control.WndProc(Message& m)
       at System.Windows.Forms.ScrollableControl.WndProc(Message& m)
       at Telerik.WinControls.RadControl.WndProc(Message& m)
       at Telerik.WinControls.UI.RadPopupControlBase.WndProc(Message& m)
       at System.Windows.Forms.Control.ControlNativeWindow.OnMessage(Message& m)
       at System.Windows.Forms.Control.ControlNativeWindow.WndProc(Message& m)
       at System.Windows.Forms.NativeWindow.DebuggableCallback(IntPtr hWnd, Int32 msg, IntPtr wparam, IntPtr lparam)
       at System.Windows.Forms.UnsafeNativeMethods.DispatchMessageW(MSG& msg)
       at System.Windows.Forms.Application.ComponentManager.System.Windows.Forms.UnsafeNativeMethods.IMsoComponentManager.FPushMessageLoop(IntPtr dwComponentID, Int32 reason, Int32 pvLoopData)
       at System.Windows.Forms.Application.ThreadContext.RunMessageLoopInner(Int32 reason, ApplicationContext context)
       at System.Windows.Forms.Application.ThreadContext.RunMessageLoop(Int32 reason, ApplicationContext context)
       at System.Windows.Forms.Application.Run(Form mainForm)
       at _1075342CopyText.Program.Main() in d:\Projects\1075342CopyText_Binding\Program.cs:line 17
       at System.AppDomain._nExecuteAssembly(RuntimeAssembly assembly, String[] args)
       at System.AppDomain.ExecuteAssembly(String assemblyFile, Evidence assemblySecurity, String[] args)
       at Microsoft.VisualStudio.HostingProcess.HostProc.RunUsersAssembly()
       at System.Threading.ThreadHelper.ThreadStart_Context(Object state)
       at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean preserveSyncCtx)
       at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
       at System.Threading.ThreadHelper.ThreadStart()
  InnerException: 

Workaround: use a GridViewDateTimeColumn 

Please refer to the attached sample project and select a new value in the drop down.

Workaround: change the PageSize in the RadDropDownListElement.PopupClosed event:

public sealed class PageSizeDropdownHeaderCellElement : GridHeaderCellElement
{
    public PageSizeDropdownHeaderCellElement(GridViewColumn col, GridRowElement row) : base(col, row)
    {
        TextAlignment = ContentAlignment.TopCenter;
        Alignment = ContentAlignment.TopCenter;
    }

    private RadDropDownListElement _dropDownListElement;

    protected override void CreateChildElements()
    {
        base.CreateChildElements();
        _dropDownListElement = new RadDropDownListElement();
        if (_dropDownListElement != null && _dropDownListElement.DataSource == null)
        {
            _dropDownListElement = new RadDropDownListElement();
            _dropDownListElement.BindingContext = new BindingContext();
            _dropDownListElement.DropDownStyle = Telerik.WinControls.RadDropDownStyle.DropDownList;

            _dropDownListElement.Items.Clear();
            _dropDownListElement.Items.Add(new RadListDataItem("10", 10) { Selected = true });
            _dropDownListElement.Items.Add(new RadListDataItem("25", 25));
            _dropDownListElement.Items.Add(new RadListDataItem("50", 50));
            _dropDownListElement.Items.Add(new RadListDataItem("100", 100));
            _dropDownListElement.Items.Add(new RadListDataItem("All", -1));

            _dropDownListElement.Margin = new Padding(15, 0, 0, 0);
            _dropDownListElement.StretchHorizontally = true;
            _dropDownListElement.NotifyParentOnMouseInput = false;
            _dropDownListElement.Popup.MouseClick += Popup_MouseClick;
            _dropDownListElement.PopupClosed += _dropDownListElement_PopupClosed; 
            this.Children.Add(_dropDownListElement);
        }
    }

    RadListVisualItem elementUnderMouse;

    private void Popup_MouseClick(object sender, MouseEventArgs e)
    {
        elementUnderMouse = _dropDownListElement.Popup.ElementTree.GetElementAtPoint(e.Location) as RadListVisualItem;
    }
    
    private void _dropDownListElement_PopupClosed(object sender, RadPopupClosedEventArgs args)
    {
        if (elementUnderMouse == null)
        {
            return;
        }
        if (_dropDownListElement.SelectedIndex == -1)
            return;

        var pageSize = Convert.ToInt32(elementUnderMouse.Data.Value);
        if (pageSize == -1)
        {
            pageSize = GridControl.RowCount;
        }
        else
        {
            pageSize = pageSize <= GridControl.RowCount ? pageSize : GridControl.RowCount;
        }
        this.RowInfo.Tag = pageSize;
        GridControl.PageSize = pageSize;
        elementUnderMouse = null;
    }
    
    protected override void SetContentCore(object value)
    {
        if (_dropDownListElement != null && this.RowInfo.Tag != null)
        {
            this._dropDownListElement.SelectedValue = (int)this.RowInfo.Tag;
        }
    }

    public override bool IsCompatible(GridViewColumn data, object context)
    {
        return data is ActionColumn && context is GridTableHeaderRowElement;
    }

    protected override Type ThemeEffectiveType     
            { 
                get    
                { 
                    return typeof(GridHeaderCellElement);     
                }
            }
}

To reproduce:
- Subscribe to the CellClick event 
- Click several times in the grid with the right mouse button. 
- At some point, the CellClick event will be executed. 

Workaround:
- Use the Click event:

private void RadGridView1_Click(object sender, EventArgs e)
{
    var args = e as MouseEventArgs;
    if (args.Button == MouseButtons.Left)
    {
        var clickedCell = radGridView1.ElementTree.GetElementAtPoint(args.Location) as GridDataCellElement;
        if (clickedCell != null)
        {
            //add your code here
        }
    }
}

To reproduce:
- Add one-to-many relations hierarchy 3 or more child templates.
- Export the grid using GridViewSpreadExport
- The child rows of the last parent row are missing.

Workaround:
Add an empty parent row at the end of the grid. 

To reproduce:
- Bind the grid to an object that contains enum property.
- Save the layout
- Restart the application and load the layout before setting the DataSource of the grid. 

Workaround:
Load the layout after the DataSource is set. 

Description: if you filter a text column with "Does not contains" operator, the produced FilterDescriptors.Expression is "ProductName NOT LIKE '%c%' OR ProductName IS NULL". However, if you try to programmatically add this expression to the RadGridView.FilterDescriptors.Expression property it doesn't filter the grid.

 Private Sub Form1_Load(sender As Object, e As EventArgs) Handles MyBase.Load 
     Me.ProductsTableAdapter.Fill(Me.NwindDataSet.Products)
     Me.RadGridView1.EnableFiltering = True 
 End Sub
 
 Private Sub RadButton1_Click(sender As Object, e As EventArgs) Handles RadButton1.Click
     Me.RadGridView1.FilterDescriptors.Expression = "ProductName NOT LIKE '%c%' OR ProductName IS NULL"
 End Sub

Workaround: don't set expression but add a FilterDescriptor: http://docs.telerik.com/devtools/winforms/gridview/filtering/setting-filters-programmatically-(simple-descriptors)


     Dim filter1 As New FilterDescriptor()
     filter1.[Operator] = FilterOperator.NotContains
     filter1.Value = "c"
     filter1.IsFilterEditor = True
     filter1.PropertyName = "ProductName"
     Me.RadGridView1.FilterDescriptors.Add(filter1)

To reproduce: populate a grid and enable multiple selection. Use cell selection. When you click the row header, the entire row (all cells from the row) is selected no matter the SelectionMode. However, if you start a selection from the row header and move the cursor, only the cells from the first column get selected. The attached gif file illustrates the behavior.  The expected behavior is that all cells from the affected columns should be selected when starting the selection from the row header.

Workaround:

Sub New()
    InitializeComponent()
    Me.RadGridView1.MultiSelect = True
    Me.RadGridView1.SelectionMode = Telerik.WinControls.UI.GridViewSelectionMode.CellSelect

    AddHandler Me.RadGridView1.MouseDown, AddressOf GridMouseDown
    AddHandler Me.RadGridView1.MouseUp, AddressOf GridMouseUp
    AddHandler Me.RadGridView1.MouseMove, AddressOf GridMouseMove
End Sub

Dim isMouseDown = False
Dim startRow As GridViewRowInfo
Dim lastHoveredCell As GridCellElement
Private Sub GridMouseDown(sender As Object, e As MouseEventArgs)
    Dim cell As GridRowHeaderCellElement = TryCast(Me.RadGridView1.ElementTree.GetElementAtPoint(e.Location), GridRowHeaderCellElement)
    If cell IsNot Nothing Then
        isMouseDown = True
        startRow = cell.RowInfo
    End If
End Sub

Private Sub GridMouseUp(sender As Object, e As MouseEventArgs)
    isMouseDown = False
    startRow = Nothing
End Sub

Private Sub GridMouseMove(sender As Object, e As MouseEventArgs)
    If isMouseDown Then 
        Dim cellUnderMouse As GridCellElement = TryCast(Me.RadGridView1.ElementTree.GetElementAtPoint(e.Location), GridCellElement)
        If cellUnderMouse IsNot Nothing AndAlso Not cellUnderMouse.Equals(lastHoveredCell) Then
            lastHoveredCell = cellUnderMouse
            Me.RadGridView1.ClearSelection()
            Me.RadGridView1.SelectedCells.BeginUpdate()
            If startRow.Index > cellUnderMouse.RowInfo.Index Then
                For index = cellUnderMouse.RowInfo.Index To startRow.Index
                    Me.RadGridView1.Rows(index).IsSelected = True
                Next
            Else
                For index = startRow.Index To cellUnderMouse.RowInfo.Index
                    For Each cell As GridViewCellInfo In Me.RadGridView1.Rows(index).Cells
                        cell.IsSelected = True
                    Next
                Next
            End If
            Me.RadGridView1.SelectedCells.EndUpdate(True)
        End If
    End If
End Sub

To reproduce: populate the grid with data and use the following code snippet:

Me.RadGridView1.EnableAlternatingRowColor = True
Me.RadGridView1.TableElement.AlternatingRowColor = Color.LightGray
Me.RadGridView1.MultiSelect = True
Me.RadGridView1.SelectionMode = Telerik.WinControls.UI.GridViewSelectionMode.CellSelect

Select multiple cells from different rows. You will notice that alternating color is not applied to the rows for which you have a selected cell. The attached gif file illustrates the behavior. 

Workaround:

Sub New() 
    InitializeComponent()
    Me.RadGridView1.MultiSelect = True
    Me.RadGridView1.SelectionMode = Telerik.WinControls.UI.GridViewSelectionMode.CellSelect
End Sub
Private Sub RadGridView1_CellFormatting(sender As Object, e As Telerik.WinControls.UI.CellFormattingEventArgs) _
Handles RadGridView1.CellFormatting
    e.CellElement.DrawFill = True
    e.CellElement.GradientStyle = Telerik.WinControls.GradientStyles.Solid
    If e.CellElement.IsSelected Then
        e.CellElement.ResetValue(LightVisualElement.BackColorProperty, ValueResetFlags.Local)
    ElseIf e.CellElement.RowInfo.Index Mod 2 = 0 Then
        e.CellElement.BackColor = Color.White
    Else
        e.CellElement.BackColor = Color.LightGray
    End If 
End Sub

Please refer to the attached gif file illustrating how to reproduce the error with the Demo application.

Workaround: this.radGridView1.UseScrollbarsInHierarchy = true;