If the user configures a list of sites inside Tools > Options > HTTPS > "Skip Decryption for hosts", this configuration list is ignored if the AutoResponder is enabled with the "Accept all connects" checkbox ticked.
This should be fixed because otherwise it's extremely difficult to figure out what's going wrong.
Incidentally, this behavior might be responsible for this issue: https://feedback.telerik.com/fiddler/1479071-fiddler-refusing-to-ignore-teams-microsoft-com-and-is-causing-my-ms-teams-app-on-windows-to-break