Open and press Enter, Up or Down:

<TelerikDropDownList Data="@( new List<string>() )"
                     @bind-Value="@SelectedValue"
                     TItem="string"
                     TValue="string"
                     Width="200px" />

<br /><br />

Open, filter by something non-existent and press Enter, Up or Down:

<TelerikDropDownList Data="@DropDownData"
                     @bind-Value="@SelectedValue"
                     TItem="string"
                     TValue="string"
                     Filterable="true"
                     Width="200px" />

@code {
    string SelectedValue { get; set; }

    List<string> DropDownData = new List<string>()
    {
        "foo",
        "bar",
        "baz"
    };
}

<TelerikDropDownList Data="@Products"
                     TItem="@Product"                     
                     TValue="@(int?)"
                     Value="@SelectedProductId"
                     ValueField="@nameof(Product.Id)"
                     TextField="@nameof(Product.Name)"
                     DefaultText="Select Product..."
                     ValueChanged="@( (int? newValue) => SelectedProductChanged(newValue) )"
                     Width="200px">
    <DropDownListSettings>
        <DropDownListPopupSettings Class="disabled-items" />
    </DropDownListSettings>
    <ItemTemplate>
        @{ var p = context as Product; }
        <div class="item-div @( !p.Active ? "disabled" : "" )"
             @onclick:preventDefault="@(!p.Active)"
             @onclick:stopPropagation="@(!p.Active)">
            @p.Name
        </div>
    </ItemTemplate>
</TelerikDropDownList>

<style>
    /* remove default item padding to prevent selection outside the template div */
    .disabled-items .k-list-item {
        padding: 0;
    }
    /* add back inner padding */
    .disabled-items .item-div {
        padding: 4px 8px;
    }
    /* style disabled items */
    .disabled-items .disabled {
        cursor: not-allowed;
        width: 100%;
        color: #ccc;
    }
</style>

@code {
    private List<Product> Products { get; set; }

    private int? SelectedProductId { get; set; }

    private async Task SelectedProductChanged(int? newValue)
    {
        var newProduct = Products.FirstOrDefault(x => x.Id == newValue);

        if (newProduct?.Active == true || !newValue.HasValue)
        {
            // select only active items or DefaultText
            SelectedProductId = newValue;
        }
        else
        {
            // skip disabled items during keyboard navigation
            var oldProductIndex = Products.FindIndex(x => x.Id == SelectedProductId);
            var newProductIndex = Products.FindIndex(x => x.Id == newValue);

            if (newProductIndex > oldProductIndex)
            {
                // skip forward
                SelectedProductId = Products[++newProductIndex].Id;
            }
            else
            {
                // skip backward
                SelectedProductId = Products[--newProductIndex].Id;
            }
        }
    }

    protected override void OnInitialized()
    {
        Products = new List<Product>();

        for (int i = 1; i <= 7; i++)
        {
            var active = i % 3 != 0;

            Products.Add(new Product()
            {
                Id = i,
                Name = (active ? "" : "Disabled ") + "Product " + i,
                Active = active
            });
        }

        base.OnInitialized();
    }

    public class Product
    {
        public int Id { get; set; }
        public string Name { get; set; }
        public bool Active { get; set; }
    }
}

@using System.Collections.ObjectModel

<h4>Option Selected: 6 @selectedSix</h4>
<br />

<TelerikDropDownList Data="@myDdlData"
                     TextField="MyTextField"
                     ValueField="MyValueField"
                     @bind-Value="@selectedSix" />

<h4>Option Selected: 7 @selectedSeven</h4>
<br />

<TelerikDropDownList Data="@myDdlData"
                     TextField="MyTextField"
                     ValueField="MyValueField"
                     @bind-Value="@selectedSeven">
</TelerikDropDownList>

<TelerikButton OnClick="@AddOption">Add Item</TelerikButton>

<ul>
    @foreach (var item in myDdlData)
    {
        <li>@item.MyValueField</li>
    }
</ul>

@code {
    int selectedSix { get; set; } = 6;
    int selectedSeven { get; set; } = 7;

    ObservableCollection<MyDdlModel> myDdlData = new ObservableCollection<MyDdlModel>(Enumerable.Range(1, 5).Select(x => new MyDdlModel { MyTextField = "item " + x, MyValueField = x }));

    protected override async Task OnInitializedAsync()
    {
        AddOption();

        await Task.Delay(TimeSpan.FromSeconds(1));

        AddOption();
    }

    void AddOption()
    {
        myDdlData.Add(new MyDdlModel { MyTextField = "item " + (myDdlData.Count + 1), MyValueField = myDdlData.Count + 1 });

        int origSelection = selectedSeven;
        selectedSeven = 0;
        StateHasChanged();
        //add this if it does not work
        //await Task.Delay(30);//wait a rendering frame
        selectedSeven = origSelection;
        //add this if it does not work
        //StateHasChanged();
    }

    public class MyDdlModel
    {
        public int MyValueField { get; set; }
        public string MyTextField { get; set; }
    }
}

<div class="box">
    <div class="row mt-3" style="align-items:center">
        <div class="col-12 col-lg-4">
            <span class="bold">ComboBox</span>
        </div>
        <div class="col">
            <TelerikComboBox Data="@myComboData" TextField="ComboTextField" ValueField="ComboValueField"
                             @bind-Value="selectedCombo" ClearButton="true" Filterable="true">
            </TelerikComboBox>
        </div>
    </div>

    <div class="row mt-3" style="align-items:center">
        <div class="col-12 col-lg-4">
            <span class="bold">DropDownList</span>
        </div>
        <div class="col">
            <TelerikDropDownList Data="@myDdlData" TextField="MyTextField" ValueField="MyValueField"
                                 @bind-Value="@selectedDropDown">
            </TelerikDropDownList>
        </div>
    </div>

    <div class="row mt-3" style="align-items:center">
        <div class="col-12 col-lg-4">
            <span class="bold">Autocomplete</span>
        </div>
        <div class="col">
            <TelerikAutoComplete Data="@Suggestions" @bind-Value="@AutoCompleteValue"
                                 ClearButton="true" />
        </div>
    </div>
</div>

@code {
    public int selectedDropDown { get; set; }
    public int selectedCombo { get; set; }
    public string AutoCompleteValue { get; set; }

    //ComboBox
    public class ComboModel
    {
        public int ComboValueField { get; set; }
        public string ComboTextField { get; set; }
    }

    IEnumerable<ComboModel> myComboData = Enumerable.Range(1, 20).Select(x => new ComboModel { ComboTextField = "item " + x, ComboValueField = x });

    //DropDownList
    public class MyDdlModel
    {
        public int MyValueField { get; set; }
        public string MyTextField { get; set; }
    }

    IEnumerable<MyDdlModel> myDdlData = Enumerable.Range(1, 20).Select(x => new MyDdlModel { MyTextField = "item " + x, MyValueField = x });

    //Autocomplete
    List<string> Suggestions { get; set; } = new List<string> {
        "Manager", "Developer", "QA", "Technical Writer", "Support Engineer", "Sales Agent", "Architect", "Designer"
    };
}