var pdfViewer = hostBorder.Child as RadPdfViewer;

if (pdfViewer != null)
{
    var canvas = viewer.ChildrenOfType<Canvas>().FirstOrDefault(x => x.GetType().Name.Contains("ContentElementsCanvas"));                
    var visualTargetsDictionaryField = canvas.GetType().GetField("pageNumberToVisualTarget", BindingFlags.NonPublic | BindingFlags.Instance);
    var visualTargetsDictionary = (Dictionary<int, List<VisualTarget>>)visualTargetsDictionaryField.GetValue(canvas);
    foreach (KeyValuePair<int, List<VisualTarget>> target in visualTargetsDictionary)
    {
        for (int i = 0; i < target.Value.Count; i++)
        {
            VisualTarget item = target.Value[i];
            item.RootVisual = null;
            item.Dispose();
        }
    }  
}
hostBorder.Child = null;
hostBorder.Child = new RadPdfViewer() { Document = newDocument };

var pageMarginsPropInfo = typeof(PagesLayoutManagerBase).GetField("pageMargins", System.Reflection.BindingFlags.Static | System.Reflection.BindingFlags.NonPublic);
pageMarginsPropInfo.SetValue(null, new Size(0, 0));

var provider = new PdfFormatProvider();
var document = provider.Import(File.ReadAllBytes(@"..\..\..\Systemvariablen.pdf"));

foreach (var item in document.AcroForm.FormFields)
{ 
    var widget = item.Widgets.First() as VariableContentWidget;
     
    if (widget != null)
    { 
        widget.AppearanceCharacteristics.Background = new RgbColor(255, 0, 0);
        widget.AppearanceCharacteristics.BorderColor = new RgbColor(0, 0, 255);
        widget.Border = new AnnotationBorder(2, AnnotationBorderStyle.Solid, null);
      
        widget.RecalculateContent(); 
    }
}

pdfViewer.Document = document;