@result
<br />
from model: @MyItem
<br />
<br />
<TelerikComboBox Data="@MyList" Value="@MyItem" ValueChanged="@( (string v) => MyValueChangeHandler(v) )" Placeholder="Choose something">
</TelerikComboBox>

@code {
    string result;
    private async Task MyValueChangeHandler(string theUserChoice)
    {
        result = string.Format("The user chose: {0}", theUserChoice);

        MyItem = null; // this should be enough

    }
    protected List<string> MyList = new List<string>() { "first", "second", "third" };
    protected string MyItem { get; set; } = "second";
}