The DataContext is not distribute to Large and Small contents in some cases. Possible workarouns: 1) Declare the DataContext of TileView in xaml, for example: <Window.DataContext> <local:MainViewModel /> </Window.DataContext> 2) Assing DataContext Binding to the three contents: <telerik:RadFluidContentControl.LargeContent> <Grid DataContext=" <telerik:RadFluidContentControl.Content> <TextBox FontSize="16" DataContext="{Binding}" <telerik:RadFluidContentControl.SmallContent> <TextBlock FontSize="12" DataContext="{Binding}"