Place a RadComboBox control in a RadPane. Make it floating and dock it again. When selection is changed, the SelectionChanged event is fired multiple times.

When filtering is enabled, enter text that doesn't exist in the items and when the focus is removed the text entered is deleted, but it should stay.
The solution of this issue was implemented by a new feature in the control which determines if the Text of the RadComboBox should be updated on LostFocus or not.
Simply set the UpdateTextOnLostFocus dependency property of the control to "False". By default its value is True and no change in behavior should be observed.
The UpdateTextOnLostFocus dependency property is available in the 2015 Q2 SP1 release.

When the ComboBox is non editable.

According to the following article, when the UpdateSelectionOnLostFocus property is set to True and you enter a text that cannot update the selection, once the control loses the focus, the typed text should stay in the textbox. 
https://docs.telerik.com/devtools/wpf/controls/radcombobox/howto/perform-selection-only-lost-focus

However, this doesn't happen if an item is already selected. In this case, the searched text is cleared. If you do not have a selection, then the text stays on lost focus. 

To work this around, you can cache the value of the RadComboBox's Text property in the PreviewLostKeyboardFocus event handler and then restore it in the LostFocus event handler. 

private string textCache;
private void RadComboBox_PreviewLostKeyboardFocus(object sender, System.Windows.Input.KeyboardFocusChangedEventArgs e)
{
	this.textCache = this.comboBox.Text;
}
private void RadComboBox_LostFocus(object sender, RoutedEventArgs e)
{
	this.comboBox.Text = this.textCache;
}

Place a RadComboBox in the GridViewColumn header and set SelectedIndex in the xaml. The SelectionChanged event is fired, but the command is not executed.

As a workaround you can set the SelectedIndex in xaml instead of on the Loaded event,

When the CheckBox is focused the issue is appearing.

Available in LIB version 2016.2.905, it will be also available in the 2016 R3 Release.

When IsEditable is set to true the SelectedItem is not updated if you delete the SelectedItem's text to match another existing item.

When the app is in full screen OOB mode the placement of the drop down portion of the ComboBox control is incorrect.

The issue can be reproduced also with the standard ComboBox:
https://connect.microsoft.com/VisualStudio/feedback/details/663870/wpf-4-0-combobox-itemtemplate-and-selectionboxitemtemplate-when-itemtemplate-is-bound#details

IsEditable=True and ReadOnly=True

RadComboBox and RadRibbonComboBox in their NonEditable mode do not reflect background set inline. A style for the ToggleButton contained in the NonEditable templates prevents the TemplateBinding from working properly as it uses a hard-coded background. For RadRibbonComboBox it is a Metro theme-only issue.