When creating tooltips dynamically it is possible that on a given condition some of them should not be shown anymore. A reference to them can be obtained through the manager (getToolTipByElement(HTMLelement)  method), but they cannot be removed. Calling dispose() removes the handlers, but the JavaScript object remanis, so re-adding a tooltip for the same element is not easily possible. There should be a method like removeToolTipByElement(HTMLelement) or removeToolTip(RadToolTipInstance) that will also remove the JavaScript object, popup element, etc.

When we have templates the generation of the clientIDs is dynamical. If some controls are removed and added back to the controls collection their clientIDs are changed. We can give a reference to the control in the Add method and onprerender the ToolTipManager could find their ClientIDs.
 E.g. the following demo: http://demos.telerik.com/aspnet-ajax/orgchart/examples/applicationscenarios/integrationwithradtooltip/defaultcs.aspx. is not working when we have DrillDown.

Many controls have items tooltip (RadComboBox, RadListBox, etc...) and every time is a pain to bind data in.

You could implement support to "DataToolTipField" .....