For the time begin the event logic can be executed with a small time out:

JavaScript

    <script type="text/javascript">
        var isFirstClick = "1";
        function OnClientSeriesClicked(sender, args) {
            setTimeout(function () {
                alert(isFirstClick);
            }, 0);
        }
    </script>
ASPX:

    <telerik:RadHtmlChart runat="server" Width="900px" Height="700px" ID="RadHtmlChart2"
        OnClientSeriesClicked="OnClientSeriesClicked">
        <PlotArea>
            <Series>
                <telerik:BarSeries>
                    <SeriesItems>
                        <telerik:CategorySeriesItem Y="10" />
                    </SeriesItems>
                </telerik:BarSeries>
            </Series>
        </PlotArea>
    </telerik:RadHtmlChart>